624741-83-9

Usage

Uses

Used in Pharmaceutical Industry:
4-Fluoro-2-Methoxybenzeneboronic acid pinacol ester, 96% is used as a reagent in the synthesis of pharmaceuticals for its versatility and reliability in producing high-quality results. Its stability and suitability for cross-coupling reactions make it a valuable component in the development of new drugs and medicinal compounds.
Used in Research Laboratories:
In research laboratories, 4-Fluoro-2-Methoxybenzeneboronic acid pinacol ester, 96% is used as a reagent in various chemical reactions and organic synthesis processes. Its high purity level and stability make it a reliable choice for researchers working on the development of new compounds and materials.
Used in Organic Synthesis:
4-Fluoro-2-Methoxybenzeneboronic acid pinacol ester, 96% is used as a reagent in organic synthesis for the production of various organic compounds. Its stability and suitability for cross-coupling reactions make it a valuable component in the synthesis of complex organic molecules and the development of new chemical processes.

Upstream product

• 456-49-5 1-fluoro-3-methoxybenzene 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 179899-07-1 4-fluoro-2-methoxyphenylboronic acid 
• 450-88-4 1-bromo-4-fluoro-2-methoxybenzene 
• 73183-34-3 bis(pinacol)diborane 

Relevant academic research and scientific papers

Effects of Tuning Intramolecular Proton Acidity on CO2Reduction by Mn Bipyridyl Species

In order to understand the effect of intramolecular proton acidity on CO2 reduction by Mn bipyridyl species, three fac-Mn(CO)3 bipyridine complexes containing intramolecular phenol groups of varying acidities were synthesized and electrochemical, spectroscopic, and computational studies were performed. While the phenol group acidity has minimal influence on the metal center, the complex containing a fluoro-substituted (more acidic) phenol, MnBr(F-HOPh-bpy)(CO)3, exhibits a decreased catalytic to peak current ratio following the second reduction in comparison to the complexes with unsubstituted or methyl-substituted phenol groups (MnBr(HOPh-bpy)(CO)3 and MnBr(Me-HOPh-bpy)(CO)3, respectively). A second process is also present in the catalytic wave for MnBr(F-HOPh-bpy)(CO)3. Furthermore, MnBr(F-HOPh-bpy)(CO)3 exhibits decreased CO production and increased H2 production in comparison to MnBr(HOPh-bpy)(CO)3. Spectroelectrochemistry under an inert atmosphere in the presence of water shows that following the first reduction, for both MnBr(F-HOPh-bpy)(CO)3 and MnBr(HOPh-bpy)(CO)3, the major product is a phenoxide-coordinated fac-(CO)3 species formed from reductive deprotonation and the minor product is a six-coordinate Mn(I) hydride. For both species, the major species following the second reduction is a five-coordinate anion believed to be the active catalyst for CO2 reduction, but the Mn(I) hydride persists as a minor species. The IR assignments are supported by theoretical calculations. These findings show that changes to the acidity of an intramolecular substituent can have significant effects on the catalytic performance and product selectivity of Mn(CO)3 bipyridine catalysts despite having minimal effect on the metal center, with a more acidic intramolecular substituent increasing H2 production at the expense of CO2 reduction.

Sequential Ir/Cu-Mediated Method for the Meta-Selective C-H Radiofluorination of (Hetero)Arenes

This article describes a sequential Ir/Cu-mediated process for the meta-selective C-H radiofluorination of (hetero)arene substrates. In the first step, Ir-catalyzed C(sp2)-H borylation affords (hetero)aryl pinacolboronate (BPin) esters. The intermediate organoboronates are then directly subjected to copper-mediated radiofluorination with [18F]tetrabutylammonium fluoride to afford fluorine-18 labeled (hetero)arenes in high radiochemical yield and radiochemical purity. This entire process is performed on a benchtop without Schlenk or glovebox techniques and circumvents the need to isolate (hetero)aryl boronate esters. The reaction was automated on a TracerLab FXFN module with 1,3-dimethoxybenzene and a meta-tyrosine derivative. The products, [18F]1-fluoro-3,5-dimethoxybenzene and an 18F-labeled meta-tyrosine derivative, were obtained in 37 ± 5% isolated radiochemical yield and >99% radiochemical purity and 25% isolated radiochemical yield and 99% radiochemical purity, and 0.52 Ci/μmol (19.24 GBq/μmol) molar activity (Am), respectively.

FUSED RING PYRIMIDINE COMPOUND, INTERMEDIATE, AND PREPARATION METHOD, COMPOSITION AND USE THEREOF

Disclosed area fused ring pyrimidine compound, and an intermediate, a preparation method, a composition and a use thereof. The fused ring pyrimidine compound is a compound as shown in formula I, a tautomer, an enantiomer, a diastereoisomer, a pharmaceutically acceptable salt, a metabolite, a metabolic precursor or a prodrug thereof, wherein the above-mentioned compound is used for the preparation of a medicine for preventing, remitting or treating one or more of immune system diseases, autoimmune diseases, cell proliferative diseases, allergic disorders and cardiovascular diseases, and the compound has a strong inhibitory effect on the Janues kinase, FGFR kinase, FLT3 kinase and Src family kinase.

IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS

A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a -NH- linkage, and substituted on the phenyl ring by one or two further substituents as defined herein, being selective ligands for GABAA receptors, in particular having good affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.