62491-96-7

Basic information

• Product Name: 1-(2-CHLORO-ETHYL)-3-PYRIDIN-4-YL-UREA
• Synonyms: N-(2-CHLOROETHYL)-N'-(4-PYRIDINYL)UREA;1-(2-CHLORO-ETHYL)-3-PYRIDIN-4-YL-UREA;N-(2-Chloroethyl)-N'-pyridin-4-ylurea
• CAS NO: 62491-96-7
• Molecular Formula: C₈H₁₀ClN₃O
• Molecular Weight: 199.64
• Mol File: 62491-96-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 102-106°C
• Boiling Point: 322.5°C at 760 mmHg
• Flash Point: 148.9°C
• Appearance: /
• Density: 1.309g/cm³
• Vapor Pressure: 0.000278mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 1-(2-CHLORO-ETHYL)-3-PYRIDIN-4-YL-UREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-CHLORO-ETHYL)-3-PYRIDIN-4-YL-UREA(62491-96-7)
• EPA Substance Registry System: 1-(2-CHLORO-ETHYL)-3-PYRIDIN-4-YL-UREA(62491-96-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 62491-96-7(Hazardous Substances Data)

Usage

General Description

1-(2-Chloro-ethyl)-3-pyridin-4-yl-urea is a chemical compound with potential medicinal properties. 1-(2-CHLORO-ETHYL)-3-PYRIDIN-4-YL-UREA is a derivative of urea, which is a molecule with two amine groups joined by a carbonyl functional group. The presence of the pyridine ring and the chloroethyl group may endow this chemical with many biological activities such as anticancer, anti-inflammatory, and antimicrobial activity, though specific data may vary based on additional research and testing. Its exact effect and usage will depend on the particular context and therefore should be handled with care and under proper precautionary measures.

InChI:InChI=1/C8H10ClN3O/c9-3-6-11-8(13)12-7-1-4-10-5-2-7/h1-2,4-5H,3,6H2,(H2,10,11,12,13)

Upstream product

• 504-24-5 4-aminopyridine 
• 1943-83-5 2-chloroethyl isothiocyanate 

Downstream Products

• 1372097-30-7 (2S)-N-[4-{1-(3-pentoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-amino benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 1372097-29-4 (2S)-N-[4-{1-(3-butoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-amino benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 1372097-28-3 (2S)-N-[4-{1-(3-propoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-aminoben-zoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 1372097-26-1 (2S)-N-[4-{1-(3-butoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-nitro-benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 1372097-25-0 (2S)-N-[4-{1-(3-propoxy)-3-(4-pyridyl)-2-imidazolidinone}-5-methoxy-2-nitro-benzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal 

Relevant articles and documents

Discovery of Potent EV71 Capsid Inhibitors for Treatment of HFMD

Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD), which can spread its infections to the central nervous and other systems with severe consequences. The viral caspid protein VP1 is a well-known target for antiviral efficacy because its occupancy by suitable compounds could stabilize the virus capsid, thus preventing uncoating of virus for RNA release. In this Letter, design, synthesis, and biological evaluation of novel anti-EV71 agents (aminopyridyl 1,2,5-thiadiazolidine 1,1-dioxides) are described. One of the most promising compounds (14) showed excellent antiviral activity against EV71 (EC50 = 4 nM) and exhibited excellent in vivo efficacy in the EV71 infected mouse model.

INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY

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Synthesis and antipicornavirus activity of (R)- and (S)-1-[5-(4′- chlorobiphenyl-4-yloxy)-3-methylpentyl]-3-pyridin-4-yl-imidazolidin-2-one

The new pyridyl imidazolidinone derivative, 1-[5-(4′-chlorobiphenyl- 4-yloxy)-3-methylpentyl]-3-pyridin-4-yl-imidazolidin-2-one (±)-1a, was synthesized and found to have an excellent antiviral activity against EV71 (IC50 = 0.009 μM). Therefore, both the enantiomers, (S)-(+)-1a and (R)-(-)-1a, have been prepared starting from readily available monomethyl (R)-3-methylglutarate (7) as a useful chiral building block and their antiviral activity was evaluated in a plaque reduction assay. Interestingly, we observed that the enantiomer (S)-(+)-1a was 10-fold more active against enterovirus71 (EV71) (IC50 = 0.003 μM) than the corresponding enantiomer (R)-(-)-1a (IC50 = 0.033 μM). Similar results were found against all five strains (1743, 2086, 2231, 4643, and BrCr) of EV71 tested. This demonstrated that the absolute configuration of the chiral carbon atom at the 3-position of the alkyl linker considerably influenced the anti-EV71 activity of these pyridyl imidazolidinones.