62500-55-4Relevant academic research and scientific papers
Synthesis and antimicrobial activity of 1,3,4-triaryl-2-azetidinones
Diurno,Mazzoni,Piscopo,Bolognese
, p. 239 - 247 (2007/10/02)
A set of substituted 1,3,4-triaryl-2-azetidinones were synthesized and characterized. Their antimicrobial activity, against Gram+ and Gram- bacteria and Fungi, was tested. The compounds 23 and 30 showed remarkable activity against Pseudomonas aeruginosa.
On the azetidin-2-one ring formation. A 1H NMR investigation
Bolognese, Adele,Diurno, M. Vittoria,Mazzoni, Orazio,Giordano, Federico
, p. 7417 - 7428 (2007/10/02)
Azetidin-2-ones were prepared by addition of phenylacetic acid chloride to substituted benzal-anilines in DMF. The effect of temperature and substituents at the benzal-anilines on the reaction mechanism was investigated carrying out the reaction in DMF d7 in an NMR probe of a Bruker 400-MHz spectrometer at 25 and 60°C. Proton signals, arising from two kinds of intermediates a 2-phenyl-N-(α-chlorobenzyl)-acetanilide (6) and a nitrogen-charged adduct (7) suggest that two competitive mechanisms play a role in the formation of trans and cis azetidin-2-ones.
