62500-89-4

Basic information

• Product Name: 2-(4-methyl-1H-indol-3-yl)ethanamine
• Synonyms: 1H-indole-3-ethanamine, 4-methyl-
• CAS NO: 62500-89-4
• Molecular Formula: C₁₁H₁₄N₂
• Molecular Weight: 174.2423
• Mol File: 62500-89-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 354.3°C at 760 mmHg
• Flash Point: 195.3°C
• Density: 1.126g/cm³
• Vapor Pressure: 3.38E-05mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 2-(4-methyl-1H-indol-3-yl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methyl-1H-indol-3-yl)ethanamine(62500-89-4)
• EPA Substance Registry System: 2-(4-methyl-1H-indol-3-yl)ethanamine(62500-89-4)

Safety Data

• Hazardous Substances Data: 62500-89-4(Hazardous Substances Data)

Usage

Indole derivative

4-MIA is a derivative of the chemical indole, which is a structural feature that many psychoactive compounds share.

Aromatic amine

2-(4-methyl-1H-indol-3-yl)ethanamine is classified as an aromatic amine, which is a type of organic compound that contains an amino group attached to an aromatic ring.

Structural similarity to tryptamines

4-MIA has a structural similarity to tryptamines, a class of compounds known for their hallucinogenic effects, which has led to its study for potential use as a psychoactive drug.

Therapeutic potential

4-MIA has been investigated for its potential as a therapeutic agent for various medical conditions, indicating that it may have some medical benefits.

Restricted use and distribution

Due to its psychoactive properties and potential for abuse, the use and distribution of 4-MIA are restricted in many countries, and the compound is subject to strict regulations and controls in many jurisdictions.

Upstream product

• 4771-48-6 4-methyl-1H-indole-3-carboxaldehyde 
• 16096-32-5 4-methyl-1H-indole 
• 23084-32-4 4-methylindole-3-acetonitrile 

Downstream Products

• 1334535-01-1 4-methyl-N-(2-(4-methyl-1H-indol-3-yl)ethyl)benzenesulfonamide 

Relevant articles and documents

Novel and potent human and rat β3-adrenergic receptor agonists containing substituted 3-indolylalkylamines

A novel series of 2-(3-indolyl)alkylamino-1-(3-chlorophenyl)ethanols was prepared and evaluated for in vitro ability to stimulate cAMP production in Chinese hamster ovary cells expressing cloned human β3-AR. The optically active 30a was found to be the most potent and selective human β3-AR agonist in this series with an EC50 value of 0.062 nM. In addition, 30a selectivity for human β3-AR was 210-fold and 103-fold that for human β2-AR and β1-AR, respectively. Furthermore, 30a showed potent agonistic activity at rat β3-AR.