625095-61-6

Basic information

• Product Name: 9-[2-[(2R,4S)-4-(3-Chlorophenyl)-2-oxido-1,3,2-dioxaphosphinan-2-ylmethoxy]ethyl]adenine mesylate
• Synonyms: Pradefovir Mesilate; MB-06866，MB-6866，Hepavir B，Remofovir mesylate; 9-(2-{[(2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphinan-2-yl]methoxy}ethyl)-9H-purin-6-amine methanesulfonate (1:1)
• CAS NO: 625095-61-6
• Molecular Formula: C₁₈H₂₃ClN₅O₇PS
• Molecular Weight: 519.8963
• Mol File: 625095-61-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 649.7°C at 760 mmHg
• Flash Point: 346.7°C
• Vapor Pressure: 9.18E-17mmHg at 25°C
• CAS DataBase Reference: 9-[2-[(2R,4S)-4-(3-Chlorophenyl)-2-oxido-1,3,2-dioxaphosphinan-2-ylmethoxy]ethyl]adenine mesylate(CAS DataBase Reference)
• NIST Chemistry Reference: 9-[2-[(2R,4S)-4-(3-Chlorophenyl)-2-oxido-1,3,2-dioxaphosphinan-2-ylmethoxy]ethyl]adenine mesylate(625095-61-6)
• EPA Substance Registry System: 9-[2-[(2R,4S)-4-(3-Chlorophenyl)-2-oxido-1,3,2-dioxaphosphinan-2-ylmethoxy]ethyl]adenine mesylate(625095-61-6)

Safety Data

• Hazardous Substances Data: 625095-61-6(Hazardous Substances Data)

Upstream product

• 625095-66-1 C₁₇H₁₉ClN₅O₄P 
• 75-75-2 methanesulfonic acid 
• 625095-60-5 (+)-cis-9-{2-[4-(S)-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-methyleneoxy]eth-1-yl}adenine 

Relevant articles and documents

LEWIS ACID MEDIATED SYNTHESIS OF CYCLIC ESTERS

Methods for the synthesis of cyclic phosphonic acid diesters from 1,3-diols are described, whereby cyclic phosphonic acid diesters are produced by reacting a chiral 1,3-diol and an activated phosphonic acid in the presence of a Lewis acid.

Novel phosphonic acid based prodrugs of PMEA and its analogues

Prodrugs of Formula I, their uses, their intermediates, and their method of manufacture are described: 1wherein: M and V are cis to one another and MPO3H2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmet