625095-72-9

Basic information

• Product Name: 9-{2-[2,4-cis(S)-(+)-4-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl]methoxyethyl}adenine maleate
• CAS NO: 625095-72-9
• Molecular Weight: 539.869
• Mol File: 625095-72-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 9-{2-[2,4-cis(S)-(+)-4-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl]methoxyethyl}adenine maleate(CAS DataBase Reference)
• NIST Chemistry Reference: 9-{2-[2,4-cis(S)-(+)-4-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl]methoxyethyl}adenine maleate(625095-72-9)
• EPA Substance Registry System: 9-{2-[2,4-cis(S)-(+)-4-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-yl]methoxyethyl}adenine maleate(625095-72-9)

Safety Data

• Hazardous Substances Data: 625095-72-9(Hazardous Substances Data)

Upstream product

• 110-16-7 maleic acid 
• 625095-60-5 (+)-cis-9-{2-[4-(S)-(3-chlorophenyl)-2-oxo-1,3,2-dioxaphosphorinan-2-methyleneoxy]eth-1-yl}adenine 

Relevant articles and documents

Process for preparation of cyclic prodrugs of PMEA and PMPA

The method of preparing compounds of Formula I is described: wherein: M and V are cis to one another and MPO3H2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmethoxyethyl)adenine, and (R)-9-(2-phosphonylmethoxypropyl)adenine; wherein V is phenyl, optionally substituted with 1-2 substituents selected from a group consisting of fluoro, chloro, and bromo; comprising: coupling a chiral 1-phenylpropane-1,3-diol, wherein the phenyl may be optionally substituted, with MPOCl2 or an N-6 substituted analogue thereof. Additionally, methods and salt forms are described that enable isolation and purification of the desired isomer.