625115-91-5

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indole-3-carbonitrile,6-amino-(9CI) is used as a building block for the synthesis of various biologically active compounds. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry Research:
1H-Indole-3-carbonitrile,6-amino-(9CI) is used as a research compound in medicinal chemistry. Its structural features make it of interest for studying the interactions between molecules and their biological targets, contributing to the understanding of drug action and the design of new therapeutic agents.
Used in Drug Development:
1H-Indole-3-carbonitrile,6-amino-(9CI) is used in drug development as a starting material for the synthesis of novel compounds with potential pharmaceutical applications. Its unique chemical properties can be exploited to create new drugs with improved efficacy and selectivity.
Used in Agrochemicals:
1H-Indole-3-carbonitrile,6-amino-(9CI) may have potential uses in agrochemicals due to its unique chemical properties. It can be explored as a component in the development of new pesticides, herbicides, or other agrochemical products.
Used in Material Sciences:
1H-Indole-3-carbonitrile,6-amino-(9CI) may also have potential applications in material sciences. Its unique chemical structure can be utilized in the development of new materials with specific properties, such as conductivity, stability, or reactivity, for various industrial applications.

Upstream product

• 4769-99-7 6-nitro-1H-indole-3-carbonitrile 
• 4769-96-4 6-nitroindole 

Relevant academic research and scientific papers

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Modulators of ATP-binding cassette transporters

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Novel indole inhibitors of IMPDH from fragments: Synthesis and initial structure-activity relationships

The elaboration of previously reported indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro inhibitory values for IMPDH II, PBMC proliferation and physicochemical properties are discussed.