6253-27-6Relevant academic research and scientific papers
A spin-crossover Co(II) complex catalyzes the activation of sp3 C–H bonds by two-electron oxidants
Bell-Taylor, Angela,Gorden, John D.,Hardy, Emily E.,Goldsmith, Christian R.
, p. 206 - 212 (2018/06/26)
We recently found that a high-spin Co(II) complex with N,N'-dibenzyl-N,N'-bis(2-pyridylmethyl)-1,2-cyclohexanediamine (bbpc) was capable of catalyzing the oxidation of weak sp3 C–H bonds by iodosobenzene (PhIO) and meta-chloroperbenzoic acid (MCPBA). The bbpc compound could also be oxidized to a Co(III)-peroxo species capable of reacting with aldehydes. The ligand N-benzenesulfonyl-N,N’-bis(2-pyridylmethyl)-1,2-cyclohexanediamine (bsbpc) reacts with Co(ClO4)2 to yield a spin-crossover complex, [Co(bsbpc)(MeCN)2](ClO4)2. The bsbpc complex catalyzes the oxidation of benzylic and allylic C–H bonds by PhIO and MCPBA to approximately the same extent as the high-spin bbpc compound. The bsbpc complex differs more substantially from the bbpc compound in that it cannot be oxidized to a stable Co(III)-peroxo complex and shows no reactivity with aldehydes.
Efficient and stereospecific synthesis of (z)-Hex-3-enedioic acid, a key intermediate for Gly-Gly cis olefin isostere
Perlman,Albeck
, p. 4443 - 4449 (2007/10/03)
(z)-Hex-3-enedioic acid, a key intermediate in the synthesis of (z)-5-amino-3-pentenoic acid (a Gly-Gly cis olefin isostere), was synthesized by a short and efficient procedure of sequential oxidations. Thus, selective mono epoxidation of 1,4-cyclohexadiene was followed by periodate oxidation to the appropriate dialdehyde. Finally, Jones oxidation of the dialdehyde afforded the corresponding diacid product.
