62533-23-7Relevant academic research and scientific papers
Palladium(II)/copper(I)-catalyzed sequential C[sbnd]H arylation and oxidative C[sbnd]N bond cleavage of aryl sulfonamino acids: Efficient one-pot synthesis of primary biaryl sulfonamides
Liu, Wei,Zhao, Yongli,Yi, Fei,Chen, Junmin
, p. 8382 - 8386 (2016)
A versatile strategy for the one-pot synthesis of primary biaryl-based sulfonamides has been developed via a tandem process consisting of palladium-catalyzed C[sbnd]H arylation and subsequent copper-catalyzed oxidative C[sbnd]N bond cleavage of aryl sulfonamino acids. Both electron-withdrawing and electron-donating functionalities can be introduced into the ortho positions of arenes bearing a variety of substituents. The amio acid moiety not only acts as a directing group but also as an ammonia synthetic equivalent. Importantly, the directing group was smoothly removed in the presence of catalytic CuI by using air as a sole oxidant.
