625366-60-1

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 32807-28-6 Methyl 4-chloroacetoacetate 
• 109-77-3 malononitrile 

Downstream Products

• 354556-65-3 6-amino-4-(3-bromo-phenyl)-5-cyano-2-(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-ylsulfanylmethyl)-4H-pyran-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

4-(3-Cyanopyridin-2-ylthio)acetoacetates in synthesis of heterocycles

Substituted 2-ammo-4-aryl-3-cyano-5-oxo-5,6-dihydro-4H-pyrano[2,3-d] pyrido[3′,2′:4,5]thieno[3,2-b]pyridines were synthesized by the reactions of 4-hydroxy-1H-thieno[2,3-b;4,5-b]dipyridin-2-ones with arylidenemalononitriles or by the three-component reactions of hydroxythienodipyridinones with aldehydes and malononitrile in DMF in the presence of Methylamine. Methods for syntheses of substituted 3-alkoxycarbonyl-6-amino-4-aryl-2-(3-cyanopyridin-2-ylthiomethyl)-4H-pyrans were developed on the basis of the reactions of 4-(3-cyanopyridin-2-ylthio) acetoacetates and arylidenemalononitriles or aldehydes and malononitrile. Ethyl 4-(3-cyanopyridin-2-ylthio)acetoacetate and 4-methoxybenzyl- idenecyanothioacetamide were used for the synthesis of 6-(pyridin-2- ylthiomethyl)-3-cyanopyridine-2(1H)-thione.