625367-49-9Relevant academic research and scientific papers
Organocatalytic enantioselective construction of multi-functionalized spiro oxindole dienes
Huang, Xiao-Fei,Zhang, Ya-Fei,Qi, Zheng-Hang,Li, Nai-Kai,Geng, Zhi-Cong,Li, Kun,Wang, Xing-Wang
, p. 4372 - 4385 (2014/06/23)
A diastereo- and enantio-selective domino Michael-cyclization- tautomerization reaction of isatylidene malononitriles with α,α- dicyanoalkenes catalyzed by a cinchona alkaloid-derived bifunctional thiourea catalyst has been developed. A series of multi-functionalized spiro oxindole diene derivatives have been obtained in good to excellent yields (up to 97%) with good to excellent enantioselectivities (up to 96%) as well as good diastereoselectivities (up to 7.9=1). In addition, an anomalous temperature effect on the enantioselectivity has also been studied for this transformation. the Partner Organisations 2014.
A novel method for the synthesis of functionalized spirocyclic oxindoles by one-pot tandem reaction of vinyl malononitriles with isatylidene malononitriles
Hari Babu, Thelagathoti,Abragam Joseph,Muralidharan,Perumal, Paramasivan T.
experimental part, p. 994 - 996 (2010/05/03)
One-pot synthesis of novel spirocyclic oxindoles was achieved via vinylogous Michael addition of vinyl malononitriles on isatin-malononitrile adducts as the key step followed by a sequential tandem reaction.
