625394-47-0Relevant academic research and scientific papers
3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists
Zhao, Shu-Hai,Berger, Jacob,Clark, Robin D.,Sethofer, Steven G.,Krauss, Nancy E.,Brothers, Julie M.,Martin, Renee S.,Misner, Dinah L.,Schwab, Dietmar,Alexandrova, Ludmila
, p. 3504 - 3507 (2007)
A series of novel 3,4-dihydro-2H-benzo[1,4]oxazine derivatives has been designed and synthesized as 5-HT6 receptor antagonists. Many of the compounds displayed subnanomolar affinities for the 5-HT6 receptor and good brain penetration in rats. The relationship of structure and lipophilicity to hERG inhibition of this series of compounds is discussed.
Benzoxazine derivatives and uses thereof
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Page 24, (2008/06/13)
The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9,
