625415-33-0Relevant academic research and scientific papers
A novel, versatile D→BCD steroid construction strategy, iIIustrated by the enantioselective total synthesis of estrone
Foucher, Vincent,Gulzzardi, Benedetta,Groen, Marinus B.,Light, Mark,Linclau, Bruno
supporting information; experimental part, p. 680 - 683 (2010/04/02)
Chemical Equation presented A general steroid synthesis Is presented that relies on prior formation of three stereogenlc centers (C8, C13, and C14) on a D ring template, followed by C- and B-ring cyclizatlons. The assembly of the key D ring template, achieved by a 3-component conjugate addition/alkylation process, allows Introduction of structural variety as required. The method Is illustrated by the total synthesis of estrone via a C-ring closing metathesis and a B-ring Heck cyclization.
