62556-24-5

Basic information

• Product Name: 1H-Indole, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-[2-oxo-2-(1-piperazinyl)ethyl]- , monohydrochloride
• CAS NO: 62556-24-5
• Molecular Formula: C23H24ClN3O3.ClH
• Molecular Weight: 462.376
• Mol File: 62556-24-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-[2-oxo-2-(1-piperazinyl)ethyl]- , monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-[2-oxo-2-(1-piperazinyl)ethyl]- , monohydrochloride(62556-24-5)
• EPA Substance Registry System: 1H-Indole, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-[2-oxo-2-(1-piperazinyl)ethyl]- , monohydrochloride(62556-24-5)

Safety Data

• Hazardous Substances Data: 62556-24-5(Hazardous Substances Data)

Downstream Products

• 1222083-97-7 N-{(succinylpodophyllotoxinyl)piperazin-4-yl}-2-{1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl}acetamide 

Relevant articles and documents

Podophyllotoxin analogues active versus Trypanosoma brucei

In an effort to discover novel anti-trypanosomal compounds, a series of podophyllotoxin analogues coupled to non-steroidal anti-inflammatory drugs (NSAIDs) has been synthesized and evaluated for activity versus Trypanosoma brucei and a panel of human cell lines, revealing compounds with low nano-molar potencies. It was discovered that coupling of NSAIDs to podophyllotoxin increased the potencies of both compounds over 1300-fold. The compounds were shown to be cytostatic in nature and seem to act via de-polymerization of tubulin in a manner consistent with the known activities of podophyllotoxin. The potencies against T. brucei correlated directly with Log P values of the compounds, suggesting that the conjugates are acting as hydrophobic tags allowing podophyllotoxin to enter the cell.