6258-43-1Relevant academic research and scientific papers
A Garratt-Braverman route to aryl naphthalene lignans
Mondal, Sayantan,Maji, Manasi,Basak, Amit
experimental part, p. 1183 - 1186 (2011/03/21)
A series of aryl naphthalene lignans were prepared in good yields starting from substituted bis-propargyl ethers. The method involved a base-mediated Garratt-Braverman cyclization followed by benzylic oxidation to the lactone. The chemoselectivity in the
Synthesis and biological activity of bromolignans and cyclolignans
San Feliciano,Medarde,Pelaez Lamamie De Clairac,Lopez,Puebla,Gravalos,Lazaro,De Quesada
, p. 421 - 426 (2007/10/02)
Nine lignan derivatives (4-12) have been obtained from (-)-yatein by treatment with DDQ and NBS. They showed moderate antineoplastic activity (P-388, A-549, HT-29) compared with podophyllotoxin, but some of them have a better therapeutic index. None of the tested compounds shows antiviral (HSV-1, VSV) or enzyme inhibitor (ADA, DHFR, GST) activities.
