625833-20-7Relevant academic research and scientific papers
Pyrimido[1,2-b]-1,2,4,5-tetrazin-6-ones as HCMV protease inhibitors: A new class of heterocycles with flavin-like redox properties
Di Grandi, Martin J.,Curran, Kevin J.,Baum, Ellen Z.,Bebernitz, Geraldine,Ellestad, George A.,Ding, Wei-Dong,Lang, Stanley A.,Rossi, Miriam,Bloom, Jonathan D.
, p. 3483 - 3486 (2003)
The synthesis and biological activity of pyrimidotetrazin-6-ones against HCMV protease is described. The mechanism of action for these inhibitors is the oxidation of several cysteine residues to generate cross-linked enzyme.
