625847-29-2Relevant academic research and scientific papers
Efficient Synthesis of Substituted Vinyl Ethers Using the Julia Olefination
Surprenant, Simon,Chan, Wing Yan,Berthelette, Carl
, p. 4851 - 4854 (2007/10/03)
(Equation Presented) Julia olefination between α sulfones 2a-c and a wide variety of ketones or aldehydes afforded substituted vinyl ethers in 46-90% yields. Sulfones 2a-c were readily prepared in two steps from commercially available reagents in 68-80% yields. Optimization revealed that the nature of the base, the solvent, and the temperature were crucial to obtaining the desired vinyl ethers.
