625852-81-5Relevant academic research and scientific papers
Synthesis of 1-(2,3-dimethyl-1-phenyl-pyrazolone-5-yl-4)-2-mercapto-1′,5- cycloalkane-spiro[1,3]thiazolo[3,4-b]-1,2,4-triazole derivatives
Shaker
, p. 1175 - 1182 (2007/10/03)
New thiosemicarbazone derivatives 3a-c, obtained by the condensation of 4-(2,3-dimethyl-1-phenyl-pyrazolone-5-yl-4)-thiosemicarbazide (1) with cycloalkanones 2a-c, on reaction with mercaptoacetic acid (4) yields the corresponding spiro thiazolidin-4-ones 5a-c. Compound 5 undergo intramolecular heterocyclization to the corresponding 1-(2,3-dimethyl-1-phenyl-pyrazolone-5-yl-4)-2-mercapto-1′,5- cycloalkane-spiro[1,3]thiazolo[3,4-b]-1,2,4-triazoles 6a-c with NaOH.
