6259-08-1

Usage

Uses

Used in Pharmaceutical Industry:
5-CHLORO-2-METHOXY-4-NITROANILINE is utilized as an intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 5-CHLORO-2-METHOXY-4-NITROANILINE serves as an intermediate for the production of agrochemical products. Its role in this industry is crucial for the development of effective and safe agricultural chemicals that protect crops and enhance yields.
Used in Dye and Pigment Production:
5-CHLORO-2-METHOXY-4-NITROANILINE is employed as a chemical building block in the creation of dyes and pigments. Its properties enable the production of a wide range of colors and hues, which are essential in various industries such as textiles, plastics, and printing.
Used in Chemical Research:
As a versatile chemical compound, 5-CHLORO-2-METHOXY-4-NITROANILINE is also used in chemical research for the exploration of new reactions and the synthesis of novel compounds. Its presence in the laboratory setting aids in expanding the understanding of organic chemistry and its applications.

InChI:InChI=1/C7H7ClN2O3/c1-13-7-3-6(10(11)12)4(8)2-5(7)9/h2-3H,9H2,1H3

Upstream product

• 22521-37-5 N-acetyl-5-chloro-4-nitro-2-anisidine 
• 6358-07-2 2-amino-4-chloro-5-nitrophenol 
• 74-88-4 methyl iodide 
• 92550-22-6 N,N'-bis-(5-chloro-2-methoxy-phenyl)-urea 

Downstream Products

• 99987-97-0 2-methoxy-5-morpholino-4-nitro-aniline 
• 68105-43-1 (5-Chloro-2-methoxy-4-nitro-phenyl)-(2,4-dinitro-naphthalen-1-yl)-amine 
• 886981-62-0 1-(5-chloro-2-methoxy-4-nitro-phenyl)-3-(5-cyano-pyrazin-2-yl)-urea 
• 410527-50-3 6-amino-2,4-dimethyl-8-methoxy-5-(3-trifluoromethylphenoxy)quinoline 
• 410527-43-4 2,4-dimethyl-8-methoxy-6-nitro-5-(3-trifluoromethylphenoxy)quinoline 
• 410527-64-9 6-(4-aminopropylamino)-2,4-dimethyl-8-methoxy-5-(3-trifluoromethylphenoxy)quinoline 
• 410527-58-1 2,4-dimethyl-8-methoxy-6-(4-phthalimidopropylamino)-5-(trifluoromethylphenoxy)quinoline 
• 774123-84-1 benzenesulfonic acid-(4-amino-5-chloro-2-methoxy-anilide) 
• 858502-46-2 benzenesulfonic acid-(4-amino-2-methoxy-5-phenylsulfanyl-anilide) 
• 855231-55-9 benzenesulfonic acid-(2-methoxy-4-nitro-5-phenylsulfanyl-anilide) 
• 855230-76-1 N,N'-(2-methoxy-5-phenylsulfanyl-p-phenylene)-bis-benzenesulfonamide 
• 57487-96-4 1-(β-chloropropionylamino) 2-methoxy 4-nitro 5-chlorobenzene 
• 101720-22-3 benzoic acid-(4-amino-2-methoxy-5-morpholino-anilide) 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Based on the X-ray crystallography of our lead compound 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-cyanopyrazin-2-yl)urea in the checkpoint kinase 1 (Chk1) enzyme, we modified R4, and to a lesser extent, R2, and R5 of the phenyl ring, and made a variety of N-aryl-N′-pyrazinylurea Chk1 inhibitors. Enzymatic activity less than 20 nM was observed in 15 of 41 compounds. Compound 8i provided the best overall results in the cellular assays as it abrogated doxorubicin-induced cell cycle arrest (IC50 = 1.7 μM) and enhanced doxorubicin cytotoxicity (IC50 = 0.44 μM) while displaying no single agent activity.

Arylcarbamate derivatives of 1-piperidineethanol as potent ligands for 5-HT4 receptors

A series of carbamate derivatives (7) of 2-(1-piperidinyl)ethyl 4- amino-5-chloro-2-methoxybenzoates, which have been described as potent agonists and antagonists of 5-HT4 receptors, were synthesized. They were evaluated using radioligand binding assays with [3H]GR 113808, a 5-HT4 receptor selective ligand, in the rat striatum and the electrically stimulated myenteric plexus longitudinal muscle of the guinea pig. In contrast to the previously described ester derivatives, a drop in the affinity for 5-HT4 receptors was observed and the compounds were inactive as agonists in the guinea pig ileum preparation. Unexpectedly, the ortho- substituted carbamates 8b,c (R' = H, RO = MeO or EtO, R'' = H) had nanomolar affinity for 5-HT4 receptors (K(i) = 8.9 ± 0.5 and 2.6 ± 0.4 nM, respectively). As reported previously, the cis- or trans-3,5-dimethyl substitution of piperidine (8n,o) was particularly favorable (K(i) = 1.1 ± 0.6 nM for both isomers). 8c is an antagonist equipotent to the 5-HT4 receptor antagonist SDZ 205-557 (1).

N-Substituted 2-methoxybenzenesulphonamides and medicaments containing them

The invention relates to new N-substituted benzenesulphonamides of general formula STR1 in which N IS 2 OR 3, R1 and R2 are hydrogen atoms, methyl, ethyl groups, or jointly form with the nitrogen a nitrogenized heterocyclic ring having 5 or 6 members, in particular a piperidino, pyrrolidino or morpholino group, R3 is a hydrogen atom, an NO2 group, an NH2 group, or a halogen, R4 is a hydrogen, a halogen, an NH2 group or a sulphonamide group. These compounds are useful as active substances of medicaments, in particular as antiemetic.

Unsymmetrical 1:2-chromium complexes containing an azo compound and an azomethine compound

Compounds of the formula: STR1 WHICH ARE EMINENTLY SUITABLE FOR DYEING NATURAL AND SYNTHETIC POLYAMIDES AND FOR COLORING SURFACE COATINGS. Dyeings on textile material are distinguished by very good lightfastness and very good fastness to wet treatments, for example fastness to water, perspiration, sea water and washing.