62590-73-2Relevant academic research and scientific papers
Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system
Harrak,Rosell,Daidone,Plescia,Schillaci,Pujol
, p. 4876 - 4890 (2007)
A series of substituted derivatives containing the 1,4-benzodioxine or pyrrole nucleus are described. All the newly synthesized compounds were examined for their in vitro and in vivo anti-inflammatory activity. Several derivatives, including (S)-2, 14 and 17, showed more anti-inflammatory activity in vivo in these assays (rat paw oedema induced by carrageenan) than the known classical anti-inflammatory agent ibuprofen, whereas other compounds like 1 were equipotent to ibuprofen. Compound 17 was the most outstanding derivative because of its remarkable in vivo anti-inflammatory activity. In this paper, we examine and discuss the structure-activity relationships and anti-inflammatory activities of these compounds.
Synthesis and antiinflammatory activity of 2,3-dihydro-1,4-benzodioxin methyl carboxylic acids
Vazquez,Rosell,Pujol
, p. 215 - 217 (2007/10/03)
Synthesis and antiinflammatory properties of new carboxylic acids containing the 2,3-dihydro-1,4-benzodioxin subunit are described. The 2-(2,3-dihydro-1,4-benzodioxin-6-yl)acetic acid was of comparable potency to Ibuprofen, in carrageenan induced rat paw edema assay.
N-Oxacyclic-alkylpiperidines as psychostimulants
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, (2008/06/13)
N-Oxacyclic-alkylpiperidyl-diazacompounds, e.g., those of the formula STR1 and salts thereof are antidepressants and psychostimulants.
2-Piperidinoalkyl-1,4-benzodioxans
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, (2008/06/13)
2-Piperidinoalkyl-1,4-benzodioxans, e.g. those of the formula STR1 AND ACID ADDITION SALTS THEREOF ARE NEUROLEPTIC AGENTS.
Neuroleptic 2-piperidinoalkyl-1,4-benzodioxans
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, (2008/06/13)
2-Piperidinoalkyl-1,4-benzodioxans, e.g. those of the formula STR1 and acid addition salts thereof are neuroleptic agents.
2-Piperidinoalkyl-1,4-benzodioxans
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, (2008/06/13)
2-Piperidinoalkyl-1,4 benzodioxans, e.g. those of the formula STR1 AND ACID ADDITION SALTS THEREOF ARE NEUROLEPTIC AGENTS.
