62595-28-2Relevant academic research and scientific papers
The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives
Walters, Matthew J.,Blobaum, Anna L.,Kingsley, Philip J.,Felts, Andrew S.,Sulikowski, Gary A.,Marnett, Lawrence J.
supporting information; experimental part, p. 3271 - 3274 (2010/03/31)
Sulindac sulfide is a benzylidene-indene that is a potent, time-dependent inhibitor of cyclooxygenases-1 and -2. Removal of the 2′-methyl group from the indene ring dramatically reduces time-dependent inhibition of both enzymes but also changes the geomet
