626-27-7

Basic information

• Product Name: HEPTANOIC ANHYDRIDE
• Synonyms: HEPTANOIC ANHYDRIDE;ENANTHIC ANHYDRIDE;OENANTHIC ANHYDRIDE;N-HEPTANOIC ANHYDRIDE;heptanoicacid,anhydride;heptanoicacidanhydride;Heptanoyl anhydride;n-Heptanoic acid anhydride
• CAS NO: 626-27-7
• Molecular Formula: C₁₄H₂₆O₃
• Molecular Weight: 242.35
• EINECS: 210-940-5
• Product Categories: Pharmaceutical Intermediates
• Mol File: 626-27-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: -12 °C
• Boiling Point: 278-282 °C
• Flash Point: 110 °C
• Appearance: Clear light yellow/Liquid
• Density: 0.917
• Vapor Pressure: 0.00723mmHg at 25°C
• Refractive Index: 1.432-1.434
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: HEPTANOIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: HEPTANOIC ANHYDRIDE(626-27-7)
• EPA Substance Registry System: HEPTANOIC ANHYDRIDE(626-27-7)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 45-36/37/39-26-28
• RIDADR: 1760
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 626-27-7(Hazardous Substances Data)

Usage

Chemical Properties

clear light yellow liquid

Preparation

To a flask containing 15.8 gm (0.2 mole) of dry pyridine and 25 ml of dry benzene is rapidly added with stirring 14.8 gm (0.1 mole) of heptanoyl chloride. The reaction is only slightly exothermic and then 13.0 gm (0.1 mole) of heptanoic acid is added dropwise (5 min) causing the temperature to rise to 60-65°C. After stirring for 10 min, the solid (pyridinium hydrochloride) is quickly filtered, washed twice with 25 ml portions of dry benzene, the benzene washings concentrated under reduced pressure, and the residue distilled to afford 19-20 gm (78-83%), b.p. 155-162°C (12 mm Hg), or 170-173°C (15 min).

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C14H26O3/c1-3-5-7-9-11-13(15)17-14(16)12-10-8-6-4-2/h3-12H2,1-2H3

Upstream product

• 111-71-7 heptanal 
• 2528-61-2 Heptanoic acid chloride 
• 111-14-8 oenanthic acid 
• 111-70-6 n-heptan1ol 
• 142-62-1 hexanoic acid 

Downstream Products

• 25255-98-5 Heptanoic acid (3-propionylamino-phenyl)-amide 
• 25256-27-3 Heptanoic acid (3-isobutyrylamino-phenyl)-amide 
• 43049-38-3 4-carboxy-2-nitrophenyl heptanoate 
• 133052-69-4 methyl 4-[(2-hexyl-1H-benzimidazol-1-yl)methyl]benzoate 
• 148216-16-4 N-<(4-morpholinyl)(phenylimino)methyl>heptanamide 
• 111-70-6 n-heptan1ol 
• 111-14-8 oenanthic acid 
• 7018-92-0 2,5-Undecanedione 
• 172470-01-8 3-heptanamido-5-methyl-4-(3', 5'-dimethylphenyl)thio-pyridin-2(1H)-one 
• 4596-16-1 17-heptanoyloxy-pregn-4-ene-3,20-dione 
• 21454-39-7 dec-2t-en-4-one-((E)-2,4-dinitro-phenylhydrazone) 
• 1031825-08-7 o-cresolphthalein diheptanoate 
• 1031825-20-3 o-isopropylphthalein diheptanoate 
• 1031825-13-4 o-cresolphthalein dihexanoate 

Relevant articles and documents

Nickel catalyzed decarboxylative alkylation of aryl triflates with anhydrides

Aliphatic acid anhydrides are the versatile building blocks and the new method for the conversion of anhydrides is thus of great significance. Herein, we report the decarboxylative alkylation of aryl triflates with aliphatic acid anhydrides via nickel catalysis. This novel method provides a facile access to construct Csp2-Csp3 bond. In addition, this method is compatible with a broad array of functional groups and exhibits good substrates scope.

One-pot electrochemical synthesis of acid anhydrides from alcohols

One-pot indirect electrochemical oxidation of alcohols in the methylene chloride–aqueous solution of sodium hydrocarbonate two-phase system in the presence of potassium iodide, 4-acetylamino-2,2,6,6-tetramethylpiperidin-1-oxyl, and 2,6-lutidine results in

A search for quantitative acylation of α-trinositol (1D-myo-inositol 1,2,6-tris(dihydrogen phosphate) pentasodium salt)

The acylation of α-trinositol is very sensitive to reaction conditions. Competing condensation reactions may give pyrophosphates and cyclic phosphates. Treatment of a tert-ammonium salt corresponding to α-trinositol with carboxylic acid anhydride and DMAP gives a good yield of the expected esters.