62615-78-5

Basic information

• Product Name: 1H-Indole, 1-(trifluoroacetyl)-
• CAS NO: 62615-78-5
• Molecular Formula: C10H6F3NO
• Molecular Weight: 213.159
• Mol File: 62615-78-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 1-(trifluoroacetyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 1-(trifluoroacetyl)-(62615-78-5)
• EPA Substance Registry System: 1H-Indole, 1-(trifluoroacetyl)-(62615-78-5)

Safety Data

• Hazardous Substances Data: 62615-78-5(Hazardous Substances Data)

Usage

Appearance

White to light yellow crystalline powder

Molecular weight

225.18 g/mol

Usage

Building block for the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds

Properties

Known for its ability to exhibit anti-inflammatory and analgesic properties, making it a potential candidate for the development of new drugs

Reagent

Used in the preparation of various indole-based compounds and considered a valuable tool in organic chemistry research

Upstream product

• 120-72-9 indole 
• 407-25-0 trifluoroacetic anhydride 
• 316795-01-4 2-(trimethylsilylethynyl)trifluoroacetanilide 
• 75934-33-7 N-(2,2-Diethoxy-ethyl)-2,2,2-trifluoro-N-phenyl-acetamide 

Downstream Products

• 120-72-9 indole 
• 76-05-1 trifluoroacetic acid 
• 109555-87-5 (1H-indol-3-yl)(naphthalene-1-yl)methanone 
• 15224-25-6 3-benzoylindole 

Relevant articles and documents

Synthesis of 2-(1-phenylvinyl)benzofurans and 2-(1-phenylvinyl)indoles as antimitotic agents by a tandem palladium-assisted coupling-cyclization reaction between 1-phenylvinyl iodides and ortho-substituted arylalkynes

A series of functionalized 2-(1-phenylvinyl)benzofurans 2 and 2-(1-phenylvinyl)indoles 3 were prepared from 1-phenylvinyl iodides and silylated alkynes in a one-pot reaction. After a desilylation step, the Sonogashira coupling reaction between the resulti

SYNTHESIS OF INDOLES FROM N-(TRIFLUOROACETYL)-2-ANILINO ACETALS

N-(trifluoroacetyl)indoles (3) are produced in high yield from appropriately ring-substituted N-(trifluoroacetyl)-2-anilino acetals (2) in boiling trifluoroacetic acid containing excess trifluoroacetic anhydride.Mild saponification provides the free indoles nearly quantitatively.The scope of the reaction is discussed.The ring closure follows solvolytic substitution of a trifluoroacetoxy group for one of the ethoxy groups in 2.The method has been extended to cyclization of N-(trifluoroacetyl)-α-anilinoacetone in hot polyphosphoric acid followed by saponification to yield 3-methylindole.