62618-72-8Relevant academic research and scientific papers
Discovery of (-)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone-A potent NR2B-selective N-methyl d-aspartate (NMDA) antagonist for the treatment of pain
Kawai, Makoto,Ando, Kazuo,Matsumoto, Yukari,Sakurada, Isao,Hirota, Masako,Nakamura, Hiroshi,Ohta, Atsuko,Sudo, Masaki,Hattori, Kazunari,Takashima, Tadashi,Hizue, Masanori,Watanabe, Shuzo,Fujita, Isami,Mizutani, Mayumi,Kawamura, Mitsuhiro
, p. 5558 - 5562 (2008/04/07)
(-)-6-[2-[4-(3-Fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone was identified as an orally active NR2B-subunit selective N-methyl-d-aspartate (NMDA) receptor antagonist. It has very high selectivity for NR2B subunits c
Bicyclic heteroaryl thiazole compounds, cardiotonic compositions including the same, and their uses
-
, (2008/06/13)
Cardiotonic fused aromatic bicyclic ring substituted thiazole compounds and their salts, methods for increasing cardiac contractility in humans and other mammals by the use of said compounds, pharmaceutical compositions including said compounds and methods for compound preparation.
6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses
-
, (2008/06/13)
Cardiotonic fused aromatic bicyclic ring substituted thiazole compounds and their salts, methods for increasing cardiac contractility in humans and other mammals by the use of said compounds, pharmaceutical compositions including said compounds and methods for compound preparation.
Carbostyril compounds and compositions containing same
-
, (2008/06/13)
A carbostyril compound of the formula (I) STR1 wherein the values of the substituents are as defined in the description, and pharmaceutically acceptable salts thereof, composition containing the compound of the formula (I) or its pharmaceutically acceptable salt as an active ingredient, and process for preparing same. The compound of the formula (I) and its pharmaceutically acceptable salts have cardiotonic effects.
