6262-21-1

Usage

Uses

Used in Biological and Medical Research:
3,4,5,6-Tetrachlorofluorescein is used as a tracer dye in biological and medical research for its ability to provide bright yellow-green fluorescence. It aids in visualizing and tracking biological processes and molecules within living organisms, enhancing the understanding of various biological phenomena.
Used in Forensic Science:
In forensics, 3,4,5,6-tetrachlorofluorescein is employed as a fluorescent marker to detect and analyze trace evidence. Its distinctive fluorescence assists in identifying and distinguishing minute samples, which is crucial in forensic investigations.
Used as a pH Indicator:
3,4,5,6-Tetrachlorofluorescein is utilized as a pH indicator due to its ability to change color in response to different pH levels. This property makes it valuable in various applications where pH monitoring is required, such as in environmental testing and chemical analysis.
Used in the Production of Colored Plastics:
3,4,5,6-Tetrachlorofluorescein is used as a colorant in the manufacturing of colored plastics. Its vibrant yellow-green hue contributes to the aesthetic appeal and functionality of various plastic products, enhancing their visual impact and performance in specific applications.

InChI:InChI=1/C20H8Cl4O5/c21-16-14(15(20(27)28)17(22)19(24)18(16)23)13-9-3-1-7(25)5-11(9)29-12-6-8(26)2-4-10(12)13/h1-6,25H,(H,27,28)

Upstream product

• 85-44-9 phthalic anhydride 
• 117-08-8 tetrachlorophthalic anhydride 
• 108-46-3 recorcinol 

Downstream Products

• 4159-77-7 Rose Bengal lactone 

Relevant academic research and scientific papers

Ti(IV) doping: An effective strategy to boost Lewis acidic performance of ZnO catalyst in fluorescein dye synthesis

Zn1-xTixO NPs were efficiently synthesized using a simple solution free mechanochemical method. The synthesized ZnO and Ti(IV)-doped ZnO catalysts are exhibited polycrystallinity, a hexagonal crystal structure, and roughly spherical agglomerates. The surface areas of the Zn1-xTixO catalysts were positively correlated with the doping percentage of Ti(IV), which also enhanced the Lewis acidity of the NPs. The catalysts exhibited excellent activity during the synthesis of fluorescein dyes. This methodology was also extended to sulfone-fluorescein dye synthesis.

NbCl5-Promoted Synthesis of Fluorescein Dye Derivatives: Spectroscopic and Spectrometric Characterization and Their Application in Dye-Sensitized Solar Cells

Fluorescein has several applications owing to its properties, such as high molar absorptivity, high fluorescence quantum yield, high photostability, and wavelengths of absorption and emission in the visible region. The syntheses of fluorescein derivatives between phenol and anhydride derivatives by using NbCl5 as a Lewis acid is described. The products have high yields and short reaction times are observed. The study of the UV/Vis and fluorescence spectra of these derivatives and their application in dye-sensitized solar cells is also described.

PROCESS FOR THE SYNTHESIS OF 4,5,6,7-TETRACHLORO-3',6'-DIHYDROXY-2',4',5'7'-TETRAIODO-3H-SPIRO[ISOBENZOFURAN-1,9'-XANTHEN]-3-ONE (ROSE BENGAL) AND RELATED XANTHENES

A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction, chromatographic or solvent concentration steps are required, and the intermediate as well as final compounds are isolated via filtration or similar means. The process requires a single organic solvent, and the steps are completed at temperatures below 100° C. The exclusion of chloride ions, of chloride free-radicals, hypochlorite ions, or hypochlorous acid as reagents or from reagents that may generate these species in situ in the presence of oxidants, prevents undesirable impurity formation. Several new compounds have been conceived and isolated using these methods. These new compounds are also formed into new medicaments.

One-pot synthesis of tetrafluoro- and tetrachlorofluorescein derivatives and their stabilization by β-cyclodextrin

A highly efficient one-pot procedure for the preparation of fluorescein-based dyes with relatively high yield was investigated. Significantly, introduction of these fluoro and chloro functional groups and forming host-guest complexes with cyclodextrins partially enhanced the photostability of these dyes. A highly efficient one-pot synthesis of fluorescein-based halogenated dyes with relatively high yield was reported. Introduction of fluoro and chloro functional groups and forming host-guest complexes with cyclodextrins enhanced their photostability. Copyright