626219-95-2

Basic information

• Product Name: tert-Butyl 4-(2-formyl-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate
• Synonyms: tert-Butyl 4-(2-formyl-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate
• CAS NO: 626219-95-2
• Molecular Formula: C₁₇H₂₁F₃N₂O₃
• Molecular Weight: 358.3554496
• Mol File: 626219-95-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 94-95 °C(Solv: hexane (110-54-3))
• Boiling Point: 435.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.256±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: 1.46±0.10(Predicted)
• CAS DataBase Reference: tert-Butyl 4-(2-formyl-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 4-(2-formyl-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate(626219-95-2)
• EPA Substance Registry System: tert-Butyl 4-(2-formyl-4-(trifluoromethyl)phenyl)piperazine-1-carboxylate(626219-95-2)

Safety Data

• Hazardous Substances Data: 626219-95-2(Hazardous Substances Data)

Upstream product

• 146137-78-2 2-fluoro-5-trifluoromethylbenzaldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 914347-13-0 C₁₂H₁₃F₃N₂O 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

(2-benzylphenyl)piperazine derivatives and use thereof

The invention discloses (2-benzylphenyl)piperazine derivatives, a use thereof, and a medicinal composition comprising above compounds. The derivatives and the medicinal composition are used for inhibiting serotonin reuptake. The invention also relates to

Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor

Benzylamine and pyridinemethylamine derivatives were synthesized and characterized as potent and selective antagonists of the melanocortin-4 receptor (MC4R). These compounds were also profiled in rodents for their pharmacokinetic properties. Two compounds with diversified profiles in chemical structure, pharmacological activities, and pharmacokinetics, 10 and 12b, showed efficacy in an established murine cachexia model. For example, 12b had a Ki value of 3.4 nM at MC4R, was more than 200-fold selective over MC3R, and had a good pharmacokinetic profile in mice, including high brain penetration. Moreover, 12b was able to stimulate food intake in the tumor-bearing mice and reverse their lean body mass loss. Our results provided further evidence that a potent and selective MC4R antagonist with appropriate pharmacokinetic properties might potentially be useful for the treatment of cancer cachexia.

Practical asymmetric synthesis of α-branched 2- piperazinylbenzylamines by 1,2-additions of organometallic reagents to N-tert-butanesulfinyl imines

2-[4-(tert-Butoxycarbonyl)piperazinyl] benzylidene-tert-butanesulfinamides underwent nucleophilic 1,2-addition with different organometallic reagents to give highly diastereomerically enriched adducts. X-ray crystallography of the resulting α-branched N-B