626225-52-3

Upstream product

• 535-11-5 Ethyl 2-bromopropionate 
• 46425-95-0 o-(benzylamino)phenol 
• 10057-04-2 (RS)-2-(2-iodophenoxy)propionic acid 
• 1374302-85-8 2-(o-iodophenoxy)acyl chloride 
• 100-46-9 benzylamine 

Relevant academic research and scientific papers

Copper-catalyzed one-pot synthesis of 2H-1,4-benzoxazin-3-(4H)-ones from 2-(o-haloaryloxy)acyl chlorides and primary amines

A facile and efficient Cu(I)-catalyzed one-pot synthesis of 2H-1,4-benzoxazin-3-(4H)-one derivatives has been developed. The condensation between 2-(o-haloaryloxy)acyl chlorides and primary amines followed by Cu(I)-catalyzed intramolecular C-N bond coupling afforded a variety of 2H-1,4-benzoxazin-3-(4H)-ones in good to excellent yields. Diversified substitutents on the 4-position could be conveniently introduced. ARKAT-USA, Inc.

K2CO3/H2O in [omim][BF4] ionic liquid: A green medium for efficient room-temperature synthesis of N-substituted 1,4-benzoxazin-3-ones

A medium consisting of K2CO3 and H2O in [omim][BF4] ionic liquid (IL) was used to synthesize N-substituted 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives from their corresponding o-aminophenols and 2-bromoalkanoates. As a result, chemoselective formation of benzoxazinones in high yields has been observed at room temperature. After the reactions and separation of the products, the IL was recovered and successfully reused in subsequent reactions without significant loss of activity.

[Omim][BF4], a green and recyclable ionic liquid medium for the one-pot chemoselective synthesis of benzoxazinones

An efficient procedure for the one-pot chemoselective synthesis of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives from their corresponding o-aminophenols is developed using DBU in the ionic liquid [omim][BF4]. Upon completion of the reaction and separation of the product, the ionic liquid is recovered and successfully reused over nine recycles without any noticeable loss of performance.