62635-27-2Relevant academic research and scientific papers
Reduction of activated carbonyl groups using alkylphosphanes as reducing agents: A mechanistic study
Wei, Yin,Liu, Xu-Guang,Shi, Min
scheme or table, p. 2386 - 2393 (2012/06/04)
A comprehensive mechanistic investigation on the reduction of activated carbonyl groups using alkylphosphanes as reducing agents has been conducted through a combination of experimental as well as computational studies. Both approaches show that this kind of reduction proceeds either through proton transfer from alkylphosphanes and cleavage by water during work-up or through another reaction pathway involving the participation of water at the initial stage and a two-fold proton transfer to afford the product. The reaction mechanism of the reduction of activated carbonyl groups using alkylphosphanes has been studied both experimentally and theoretically. The reduction was shown to proceed either through proton transfer from alkylphosphanes and cleavage by water during work-up or through the participation of water at the initial stage and a two-fold proton transfer.
METHOD OF PRODUCING DIOL, POLYDIOL, SECONDARY ALCOHOL OR DIKETONE COMPOUND
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Page/Page column 10-11, (2009/06/27)
The invention is a process of using, as a reducing agent, a 12CaO·7Al2O3 electride containing electrons in a number of 1019 cm-3 or more and 2.3 × 1021 cm-3 or less in its cages to subject a carbonyl compound to reductive coupling in a solvent, thereby synthesizing a diol or polydiol. The invention is also a process of reducing a ketone compound in a solvent, thereby synthesizing a secondary alcohol or diketone compound. According to the process of the invention, it is possible to synthesize a diol or polydiol, or a secondary alcohol or diketone compound through simple operations in a short period without using an expensive and harmful metal hydride or metal salt nor limiting the atmosphere for the synthesis to an inert gas atmosphere as in conventional processes.
