62640-06-6Relevant academic research and scientific papers
Effects of ajugarins and related neoclerodane diterpenoids on feeding behaviour of Leptinotarsa decemlineata and Spodoptera exigua larvae
Caballero, Cristina,Castaera, Pedro,Ortego, Felix,Fontana, Gianfranco,Pierro, Paola,Savona, Giuseppe,Rodriguez, Benjamin
, p. 249 - 256 (2001)
Three naturally occurring ajugarins and seven semisynthetic derivatives of them, possessing different functionalities in the decalin part, together with two natural furoneoclerodane diterpenes, have been assessed as feeding behavior modifying agents of larvae of the generalist Spodoptera exigua and a specialist like Leptinotarsa decemlineata. Ajugarin I and some of its derivatives exhibited a significant antifeedant activity against larvae of S. exigua in both choice and no-choice assays. Conversely, the furoneoclerodane diterpenes only presented antifeedant activity against larvae of L. decemlineata. These results indicate that the biological action of the tested substances is strongly modulated by minimal structural variations, which are also responsible for the specificity of action.
Hydrogenation derivatives of neo-clerodanes and their antifeedant activity
Bruno, Maurizio,Rosselli, Sergio,Pibiri, Ivana,Piozzi, Franco,Simmonds, Monique S. J.
, p. 599 - 612 (2007/10/03)
Hydrogenation of some natural neo-clerodanes on 10percent Pd/C resulted in the saturation of the furan ring and in some cases hydrogenolysis of the epoxide system and or γ-lactone ring. Overall, reduction of the furan ring found in the natural compounds resulted in a decrease in the antifeedant activity of the compounds against the lepidopteran pests, Heliocoverpa armigera and Spodoptera frugiperda. However, two of the most active derivatives had both the furan ring and the lactone ring hydrogenated but the epoxide intact.
