62641-66-1

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
2(1H)-Pyrimidinone, tetrahydro-1-nitrosois used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique molecular structure and potential biological activities make it a promising candidate for the development of new drugs.
Used in Anticancer Applications:
2(1H)-Pyrimidinone, tetrahydro-1-nitrosois used as a potential anticancer agent due to its biological activities. Further research and studies are needed to fully understand its properties and potential uses in this field.
Used in Antimicrobial Applications:
2(1H)-Pyrimidinone, tetrahydro-1-nitrosois used as a potential antimicrobial agent due to its biological activities. Further research and studies are needed to fully understand its properties and potential uses in this field.

InChI:InChI=1/C4H7N3O2/c8-4-5-2-1-3-7(4)6-9/h1-3H2,(H,5,8)

Upstream product

• 1852-17-1 3,4,5,6-tetrahydropyrimidin-2(1H)-one 

Downstream Products

• 189026-84-4 benzyl 2-(6-methoxyindazol-4,7-dion-3-yl)-N-ethylcarbamate 

Relevant academic research and scientific papers

Aza-analogues of the marine pyrroloquinoline alkaloids wakayin and tsitsikammamines: Synthesis and topoisomerase inhibition

Two aza-analogues of the marine pyrroloquinoline alkaloids wakayin and tsitsikammamines A and B have been synthesized. The strategy used was based on a 1,3-dipolar cycloaddition reaction between indole 4,7-dione and a diazo-aminopropane derivative. One of

Synthesis of 3-[(N-carboalkoxy)ethylamino]-indazole-dione derivatives and their biological activities on human liver carbonyl reductase

A series of indazole-dione derivatives were synthesized by the 1,3-dipolar cycloaddition reaction of appropriate substituted benzoquinones or naphthoquinones and N-carboalkoxyamino diazopropane derivatives. These compounds were evaluated for their effects on human carbonyl reductase. Several of the analogs were found to serve as substrates for carbonyl reductase with a wide range of catalytic efficiencies, while four analogs display inhibitory activities with IC50 values ranging from 3-5 μM. Two of the inhibitors were studied in greater detail and were found to be noncompetitive inhibitors against both NADPH and menadione with KI values ranging between 2 and 11 μM. Computational studies suggest that conformation of the compounds may determine whether the indazole-diones bind productively to yield product or nonproductively to inhibit the enzyme.