62658-92-8

Usage

InChI:InChI=1/C7H7NOS/c1-10-7-6(5-9)3-2-4-8-7/h2-5H,1H3

Upstream product

• 74470-23-8 2-(methylthio)nicotinic acid 
• 61856-53-9 1-t-butyl-3-formyl-2-(1H)pyridinethione 
• 128071-75-0 2-bromopyridine-3-carboxaldehyde 
• 74-88-4 methyl iodide 
• 61856-52-8 3-formyl-pyridine-2(1H)-thione 

Downstream Products

• 104246-14-2 5'-(Bis-allyloxy-phosphoryl)-2',6'-dimethyl-2-methylsulfanyl-1',4'-dihydro-[3,4']bipyridinyl-3'-carboxylic acid 2-(benzyl-methyl-amino)-ethyl ester 
• 688356-98-1 methyl 4-(methylthio)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate 

Relevant academic research and scientific papers

METHOD OF TREATING ATHEROSCLEROSIS, DYSLIPIDEMIAS AND RELATED CONDITIONS

A method of treating atherosclerosis is disclosed wherein nicotinic acid or another nicotinic acid receptor agonist is administered to the patient in combination with a DP receptor antagonist. The DP receptor antagonist is administered to reduce, prevent

NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT

The present invention encompasses compounds of Formula (I); as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating dyslipidemias. Pharmaceutical compositions and methods of use are also included.

NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT

The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating dyslipidemias. Pharmaceutical compositions and methods of use are also included.

Method of treating atherosclerosis, dyslipidemias and related conditions

A method of treating atherosclerosis is disclosed wherein nicotinic acid or another nicotinic acid receptor agonist is administered to the patient in combination with a DP receptor antagonist. The DP receptor antagonist is administered to reduce, prevent or eliminate flushing that may otherwise occur.

Parallel synthesis of aldehydes and ketone facilitated by a new solid- phase Weinreb amide

This paper describes a novel supported Weinreb amide resin that facilitates parallel synthesis of aldehydes and ketones on a scale useful for chemical library synthesis. This new resin makes it possible to produce custom aldehydes and ketones from a wide range of carboxylic acids, including N-BOC-amino acids. A variety of commercially unavailable aldehydes are easily synthesized in parallel and obtained in high purity via a simple filtration workup, thus facilitating parallel synthesis of lead optimization libraries that typically require custom synthesis of aldehyde intermediates for development of structure-activity relationships. To demonstrate the utility of this method, we synthesized a small library based on a supported Horner- Emmons reagent. This is the first time it has been shown that aldehydes generated via a supported Weinreb amide could be used directly as reagents in chemical library synthesis employing moisture-sensitive reactions. The analogous solution reaction is not suited for parallel synthesis because of the laborious extractive workup procedure necessary and, at times, the instability of these reactive intermediates.