62666-20-0 Usage
Description
Progabide is a broad-spectrum anticonvulsant agent indicated for the treatment of
a wide variety of seizure disorders. Synthesized as a GABA-prodrug, anticonvulsant
activity appears due to the parent drug and its acid metabolite, as
well as to GABAmide and GABA liberated therefrom.
Chemical Properties
Bright Yellow Solid
Originator
Synthelabo (France)
Uses
Progabide is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity.
Brand name
Gabren (Synthelabo Pharmacie, France);Gabaphore;Sl 76 002;GABRENE.
World Health Organization (WHO)
Progabide, an anticonvulsant, was introduced in France in 1985
for the treatment of epilepsy. Its use has occasionally been associated with
clinically evident signs of icteric hepatitis developing within the first six months of
treatment. These signs are generally reversible on withdrawal of the drug but
continuation of treatment has been associated with three reported fatalities (two of
which are doubtfully related to the drug). The manufacturer revised the data sheet
in March 1986 advising that use of progabide should be reserved for patients
unresponsive to other anticonvulsants.
Check Digit Verification of cas no
The CAS Registry Mumber 62666-20-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,6,6 and 6 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 62666-20:
(7*6)+(6*2)+(5*6)+(4*6)+(3*6)+(2*2)+(1*0)=130
130 % 10 = 0
So 62666-20-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H16ClFN2O2/c18-12-5-3-11(4-6-12)17(21-9-1-2-16(20)23)14-10-13(19)7-8-15(14)22/h3-8,10,22H,1-2,9H2,(H2,20,23)/b21-17+
