6267-99-8Relevant academic research and scientific papers
Efficient synthetic route to aromatic secondary amines: Via Pd/RuPhos/TBAB-catalyzed cross coupling
Gaur, Pinki,Durga Bhaskar Yamajala,Banerjee, Shaibal
, p. 6523 - 6529 (2017/07/17)
Herein, C-N cross coupling methodology was developed for the synthesis of a diverse range of nitro-substituted secondary amines. A variety of strained, aliphatic, and aromatic precursors were effectively used, with low catalyst and ligand loading ratios resulting in product formation in good yield. This method can act as an alternative to nucleophilic addition reactions. To cross couple electron-donating, electron-withdrawing, neutral, and aliphatic primary amines with alkyl/aryl halides, a combination of RuPhos and TBAB was carefully tuned. Further, characterization of these molecules was carried out using FT-IR, 1H-NMR, 13C-NMR, 19F-NMR, single crystal XRD, and C, H, and N elemental analyses.
Oxidative arylamination of 1,3-dinitrobenzene and 3-nitropyridine under anaerobic conditions: The dual role of the nitroarenes
Gulevskaya, Anna V.,Tyaglivaya, Inna N.,Verbeeck, Stefan,Maes, Bert U.W.,Tkachuk, Anna V.
experimental part, p. 238 - 251 (2011/08/22)
1,3-Dinitrobenzene and 3-nitropyridine react with lithium arylamides under anaerobic conditions to produce N-aryl-2,4-dinitroanilines and N-aryl-5-nitropyridin-2-amines, respectively, in 8-42% yields. ARKAT-USA, Inc.
