62681-98-5

Basic information

• Product Name: 2,5-BIS(2-FLUOROPHENYL)-1,3,4-OXADIAZOLE 99
• Synonyms: 1,3,4-Oxadiazole, 2,5-bis(2-fluorophenyl)-;2,5-di-(2-Fluorophenyl)-1,3,4-oxadiazole;2,5-BIS(2-FLUOROPHENYL)-1,3,4-OXADIAZOLE 99;2,5-Bis(2-fluorophenyl)-1,3,4-oxadiazole 99%
• CAS NO: 62681-98-5
• Molecular Formula: C₁₄H₈F₂N₂O
• Molecular Weight: 258.2229264
• EINECS: 263-694-6
• Mol File: 62681-98-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 118-120
• Boiling Point: 382.1°Cat760mmHg
• Flash Point: 184.9°C
• Appearance: /
• Density: 1.306g/cm³
• Vapor Pressure: 1.07E-05mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: 2,5-BIS(2-FLUOROPHENYL)-1,3,4-OXADIAZOLE 99(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-BIS(2-FLUOROPHENYL)-1,3,4-OXADIAZOLE 99(62681-98-5)
• EPA Substance Registry System: 2,5-BIS(2-FLUOROPHENYL)-1,3,4-OXADIAZOLE 99(62681-98-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 62681-98-5(Hazardous Substances Data)

Usage

General Description

The chemical 2,5-BIS(2-FLUOROPHENYL)-1,3,4-OXADIAZOLE 99 is a compound that belongs to the class of oxadiazoles, which are heterocyclic organic compounds containing an oxygen and two nitrogen atoms in a five-membered ring. It is a 99% pure form of the chemical, indicating a high level of purity. 2,5-BIS(2-FLUOROPHENYL)-1,3,4-OXADIAZOLE 99 has potential applications in the field of pharmaceuticals, material science, and agrochemicals due to its unique chemical structure and properties. It is also used as a research reagent in various scientific studies and experiments. Its high purity level makes it suitable for use in sensitive analytical techniques and synthesis processes.

InChI:InChI=1/C14H8F2N2O/c15-11-7-3-1-5-9(11)13-17-18-14(19-13)10-6-2-4-8-12(10)16/h1-8H

Upstream product

• 445-29-4 o-fluoro-benzoic acid 
• 446-24-2 2-fluorobezohydrazide 
• 393-52-2 2-Fluorobenzoyl chloride 

Downstream Products

• 1454693-84-5 C₄₄H₂₉N₅ 

Relevant articles and documents

Design, synthesis, modelling studies and biological evaluation of 1,3,4-oxadiazole derivatives as potent anticancer agents targeting thymidine phosphorylase enzyme

A series of novel 1,3,4-oxadiazole derivatives with substituted phenyl ring were designed and synthesized with an objective of discovering newer anti-cancer agents targeting thymidine phosphorylase enzyme (TP). The 1,3,4-oxadiazole derivatives were synthesized by simple and convenient methods in the lab. Chemical structure of the all the synthesized compounds were characterized by IR, 1H NMR and mass spectral methods and evaluated for cytotoxicity by MTT method against two breast cancer cell lines (MCF-7 and MDA-MB-231). Further, results of TP assay identified that 1,3,4-oxadiazole molecules displayed anti-cancer activity partially by inhibition of phosphorylation of thymidine. The TP assay identified SB8 and SB9 as potential inhibitors with anti-cancer activity against both the cell lines. The molecular docking studies recognized the orientation and binding interaction of molecule at the active site amino acid residues of TP (PDB: 1UOU). Acute toxicity studies of compound SB8 at the dose of 5000 mg/kg has identified no signs of clinical toxicity was observed. The SARs study of synthesized derivatives revealed that the substitution of phenyl ring with electron withdrawing group at ortho position showed significant TP inhibitory activity compared to para substitution. The experimental data suggests that 1,3,4-oxadiazole with substituted phenyl can be taken as a lead for the design of efficient TP inhibitors and active compounds which can be taken up for further studies.

CARBAZOLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE

A carbazole derivative is provided. The carbazole derivative is shown in formula (9):

An efficient one pot synthesis of 1,3,4-oxadiazoles

Various 1,3,4-oxadiazoles have been synthesized in excellent yields by BF3·Et2O promoted cyclodehydration of 1,2-diacyl and diaroyl hydrazines prepared in situ from corresponding acid chlorides and hydrazine.