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Usage

Uses

Used in Pharmaceutical Industry:
HUMAN G-CSF is used as a therapeutic agent for the treatment of neutropenia, a condition characterized by an abnormally low count of neutrophils in the blood. It is particularly useful in patients undergoing chemotherapy or radiation therapy, as these treatments can lead to a decrease in neutrophil levels, increasing the risk of infections.
Used in Biotechnology Industry:
HUMAN G-CSF is used as a growth factor in the culturing of human neutrophils, which is essential for research and development in the field of immunology and hematology. It helps in the proliferation and differentiation of neutrophil precursors, providing a valuable tool for studying the mechanisms of neutrophil production and function.
Used in Regenerative Medicine:
HUMAN G-CSF is used as a component of the double layer granulocyte-macrophage colony-forming unit (CFU-GM) culture system for CD34+ cells. This system is crucial for the expansion and differentiation of hematopoietic stem cells, which have the potential to develop into various blood cell types, including neutrophils. This application is particularly relevant in the field of regenerative medicine, where the ability to generate functional blood cells from stem cells is of great interest.
Used in Preclinical Research:
HUMAN G-CSF is used in chronic liver damage models to test its protective effects. Chronic liver diseases, such as cirrhosis and hepatitis, can lead to a decrease in the production of neutrophils, impairing the body's ability to fight infections. By studying the effects of HUMAN G-CSF in these models, researchers can gain insights into its potential therapeutic applications in the treatment of liver diseases and their associated complications.

Biochem/physiol Actions

Granulocyte colony-stimulating factor human (GCSF) interacts specifically with the immunoglobin (Ig) domain of the granulocyte colony-stimulating factor receptor (GCSFR).