62702-83-4

Usage

Uses

Used in Analytical Chemistry:
2-(2H-Pyran-4(3H,5H,6H)-ylidene)-malononitrile is used as a pH indicator and fluorescence probe for its ability to change color in response to variations in pH levels, which is crucial for monitoring and controlling chemical reactions and processes.
Used in Chemical Synthesis:
In the synthesis of organic compounds, 2-(2H-Pyran-4(3H,5H,6H)-ylidene)-malononitrile is used as a reagent, contributing to the formation of new chemical entities that are vital in various industries, including pharmaceuticals and materials science.
Used in Metal Ion Detection:
2-(2H-Pyran-4(3H,5H,6H)-ylidene)-malononitrile is used as a complexing agent for its capacity to form complexes with various metal ions. This property is valuable in analytical chemistry for detecting and quantifying metal ions in samples.
Used in Photochemistry and Photophysics:
2-(2H-Pyran-4(3H,5H,6H)-ylidene)-malononitrile has been studied for its potential applications in the field of photochemistry and photophysics, where its interaction with light can lead to novel applications in areas such as solar energy conversion and light-sensitive materials.
Used in Research and Development:
2-(2H-Pyran-4(3H,5H,6H)-ylidene)-malononitrile is utilized in research settings to explore its properties and potential uses, including its behavior in different chemical environments and its interactions with other compounds.

InChI:InChI=1/C8H8N2O/c9-5-8(6-10)7-1-3-11-4-2-7/h1-4H2

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 109-77-3 malononitrile 

Downstream Products

• 150986-82-6 2-amino-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carbonitrile 

Relevant academic research and scientific papers

METHODS AND COMPOSITIONS FOR TERPENOID SYNTHESIS

In one aspect, the disclosure relates to methods for preparation of terpene and terpene-like molecules. In a further aspect, the disclosure relates to the products of the disclosed methods, i.e., terpene and terpene-like molecules prepared using the disclosed methods. Intermediates for the synthesis of a wide variety of terpenoids are γ-allyl Knoevenagel adducts or quasi γ-allyl Knoevenagel adducts are disclosed. In various aspects, methods of preparing terpenoids through these intermediates are disclosed. The methods can comprise α-alkylation of an allylic electrophile followed by ring-closure metathesis to a polycyclic terpenoid structure. In a further aspect, the disclosure pertains to terpenoid frameworks, and compounds prepared via disclosed oxidation and substitution reactions on the disclosed terpenoid frameworks. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Assembly of Terpenoid Cores by a Simple, Tunable Strategy

Oxygenated, polycyclic terpenoid natural products have important biological activities. Although total synthesis of such terpenes is widely studied, synthetic strategies that allow for controlled placement of oxygen atoms and other functionality remains a challenge. Herein, we present a simple, scalable, and tunable synthetic strategy to assemble terpenoid-like polycycloalkanes from cycloalkanones, malononitrile, and allylic electrophiles, abundantly available reagent classes.

Aqueous DABCO, an efficient medium for rapid organocatalyzed Knoevenagel condensation and the Gewald reaction

In the presence of water and 1,4-diazabicyclo[2.2.2]octane, several aldehydes and cyclic ketones underwent efficient Knoevenagel condensation with malononitrile and ethyl cyanoacetate to produce the respective α.β-unsaturated systems within fairly short time periods. As a result, high yields of conjugated products were easily obtained. Products could be engaged in a Gewald reaction, either stepwise or in situ, to produce efficiently their respective 2-aminothiophenes within 4-7 h. TUeBITAK.

Ultrasound promoted synthesis of some novel fused pyrans

Novel fused pyrans were synthesized from the reaction of the tetrahydropyran-4-one with arylidine malononitriles. Different fused pyran derivatives were obtained from the mentioned reaction depending on type of catalyst used and type of energy used. Reactions were carried out under silent and ultrasonic conditions. In general, it was found that sometimes ultrasound irradiations change the reaction path in comparing with silent condition. In addition to improvement in reaction times, the products were obtained in high yields and their structures were determined by elemental analyses, spectral data.