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62732-43-8

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62732-43-8 Usage

General Description

1,2,3,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8-amine hydrate (1:1) is a chemical compound that contains a tricyclic ring structure. It is a hydrate salt with a 1:1 ratio of the amine compound and water molecules. The compound has potential applications in medicinal chemistry and pharmaceuticals due to its unique structure and properties. It may have biological activities that make it an interesting target for drug development, and its hydrate form may offer advantages in solubility and stability for pharmaceutical formulations. Further research and investigation are needed to fully understand the potential uses and properties of this compound.

Check Digit Verification of cas no

The CAS Registry Mumber 62732-43-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,7,3 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 62732-43:
(7*6)+(6*2)+(5*7)+(4*3)+(3*2)+(2*4)+(1*3)=118
118 % 10 = 8
So 62732-43-8 is a valid CAS Registry Number.

62732-43-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,2,3,5,6,7-hexahydrodicyclopenta[2,1-b:2',1'-f]pyridin-8-amine,hydrate

1.2 Other means of identification

Product number -
Other names 8-Amino-1,2,3,5,6,7-hexahydrodicyclopenta(b,e)pyridine hydrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:62732-43-8 SDS

62732-43-8Downstream Products

62732-43-8Relevant articles and documents

Recyclization of 2,2-Disubstituted 4(3H)-Oxo- and 4-Chloro-1,2-dihydropyrimidines to 4-Aminopyridine Derivatives

Upadysheva, A. V.,Grigor'eva, N. D.,Ryabokobylko, Yu. S.,Znamenskaya, A. P.

, p. 95 - 99 (1983)

The intramolecular cationotropic rearrangement of salts of two-ring 2,2-disubstituted 4-chloro-1,2-dihydropyrimidines to 4-aminopyrimidine derivatives was observed.Recyclization to 4-aminopyridines can take place in the reaction of two-ring 2,2-disubstituted 4(3H)-oxo-1,2-dihydropyrimidines with phosphorus oxychloride without isolation of the intermediate chloro derivatives.A probable mechanism that makes it possible to assert that the observed recyclization is a variant of the intramolecular cationotropic rearrangement that is characteristic for 2,2-dialkylsubstituted 1,2-dihydropyrimidines with functional substituents (for example, oxo or chloro) in the 4 position of the ring is discussed.

SULFONIMIDAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

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Page/Page column 530-533, (2020/08/13)

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: (Formula AA) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors

Harrison, David,Boutard, Nicolas,Brzozka, Krzysztof,Bugaj, Marta,Chmielewski, Stefan,Cierpich, Anna,Doedens, John R.,Fabritius, Charles-Henry R.Y.,Gabel, Christopher A.,Galezowski, Michal,Kowalczyk, Piotr,Levenets, Oleksandr,Mroczkowska, Magdalena,Palica, Katarzyna,Porter, Roderick A.,Schultz, David,Sowinska, Marta,Topolnicki, Grzegorz,Urbanski, Piotr,Woyciechowski, Jakub,Watt, Alan P.

supporting information, (2020/10/02)

The NLRP3 inflammasome is a component of the innate immune system involved in the production of proinflammatory cytokines. Aberrant activation by a wide range of exogenous and endogenous signals can lead to chronic, low-grade inflammation. It has attracted a great deal of interest as a drug target due to the association with diseases of large unmet medical need such as Alzheimer's disease, Parkinson's disease, arthritis, and cancer. To date, no drugs specifically targeting inhibition of the NLRP3 inflammasome have been approved. In this work, we used the known NLRP3 inflammasome inhibitor CP-456,773 (aka CRID3 or MCC 950) as our starting point and undertook a Structure-Activity Relationship (SAR) analysis and subsequent scaffold-hopping exercise. This resulted in the rational design of a series of novel ester-substituted urea compounds that are highly potent and selective NLRP3 inflammasome inhibitors, as exemplified by compounds 44 and 45. It is hypothesized that the ester moiety acts as a highly permeable delivery vehicle and is subsequently hydrolyzed to the carboxylic acid active species by carboxylesterase enzymes. These molecules are greatly differentiated from the state-of-the-art and offer potential in the treatment of NLRP3-driven diseases, particularly where tissue penetration is required.

Ionization constants of the drugs amiridin and tacrine and their analogs

Goncharenko,Kaganskii,Portnov,Granik

, p. 769 - 772 (2007/10/02)

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