62738-32-3Relevant academic research and scientific papers
Radical cascade synthesis of azoles: via tandem hydrogen atom transfer
Chen, Andrew D.,Herbort, James H.,Mustafa, Darsheed N.,Nagib, David A.,Nakafuku, Kohki M.,Wappes, Ethan A.
, p. 2479 - 2486 (2020/03/19)
A radical cascade strategy for the modular synthesis of five-membered heteroarenes (e.g. oxazoles, imidazoles) from feedstock reagents (e.g. alcohols, amines, nitriles) has been developed. This double C-H oxidation is enabled by in situ generated imidate
A domino copper-catalyzed C-N and C-O cross-coupling for the conversion of primary amides into oxazoles
Schuh, Kerstin,Glorius, Frank
, p. 2297 - 2306 (2008/02/13)
A variety of oxazoles can efficiently be prepared, in a single step and in good yield, from primary amides and 1,2-dihaloalkenes using copper-catalysis. This new method allows the regioselective formation of a range of substituted oxazoles. The required 1,2-dihaloalkenes can prepared by simple treatment of alkynes with elemental bromine or iodine. Georg Thieme Verlag Stuttgart.
Reactions of Diphenyl(phenylethynyl)selenonium Salts with Active Methylene Compounds and Amides: First Isolation of Oxyselenuranes [10-Se-4(C3O)] as a Reaction Intermediate
Kataoka, Tadashi,Watanabe, Shin-Ichi,Yamamoto, Keiichirou,Yoshimatsu, Mitsuhiro,Tanabe, Genzoh,Muraoka, Osamu
, p. 6382 - 6386 (2007/10/03)
The reaction of the diphenyl(phenylethynyl)selenonium triflate 1a with active methylene compounds 5 and t-BuOK in THF gave furan derivatives 6. The [10-Se-4(C3O)l selenuranes 8a and 8b could be isolated from the reactions with benzoylacetonitrile 5f and with 1,3-indandione 5g, respectively, as reaction intermediates. The structures of the selenuranes 8 were elucidated by X-ray crystallography and 77Se high-resolution solid-state NMR spectroscopy. The selenuranes 8 underwent ligand coupling on standing at room temperature or refluxing in chloroform and gave the furan derivatives 6 and the ring-opened product 9. Similarly, the reaction of 1a with benzamide 13a and pivalamide 13d in the presence of NaH in THF afforded oxazole derivatives 14.
