6274-00-6

Usage

Uses

Used in Pharmaceutical Industry:
4-methyl-3-(2-oxo-2-phenylethyl)-1,3-thiazol-3-ium is used as a potential active pharmaceutical ingredient for its possible antimicrobial and antitumor properties. 4-methyl-3-(2-oxo-2-phenylethyl)-1,3-thiazol-3-ium's structure, featuring a thiazolium cation and a 2-oxo-2-phenylethyl group, may contribute to its reactivity and interaction with biological targets, making it a candidate for the development of new drugs.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 4-methyl-3-(2-oxo-2-phenylethyl)-1,3-thiazol-3-ium serves as a subject of study for its potential to be modified and optimized for specific therapeutic applications. Its unique substitution pattern allows for the exploration of various chemical modifications that could enhance its biological activity or improve its pharmacokinetic properties.

Upstream product

• 693-95-8 4-Methylthiazole 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 57132-49-7 5ξ-benzoyl-3-methyl-7-phenyl-(5ar,8ac,8bt)-5,5a,8a,8b-tetrahydro-pyrrolo[3',4':3,4]pyrrolo[2,1-b]thiazole-6,8-dione 
• 57132-50-0 4-methyl-3-(2-oxo-2-phenyl-1-phenylcarbamoyl-ethyl)-thiazolium betaine 
• 57132-51-1 4-methyl-3-[2-oxo-2-phenyl-1-(phenyl-thiocarbamoyl)-ethyl]-thiazolium betaine 
• 57132-34-0 1-(cis-2-ethoxycarbonyl-vinyloxy)-4-methyl-1-phenyl-1H-pyrrolo[2,1-c][1,4]thiazine-7-carboxylic acid ethyl ester 
• 57132-30-6 Dimethyl 1-hydroxy-4-methyl-1-phenyl-1H-pyrrolo<2,1-c>-1,4-thiazine-7,8-dicarboxylate 
• 57132-38-4 1-(cis-2-carboxy-vinyloxy)-4-methyl-1-phenyl-1H-pyrrolo[2,1-c][1,4]thiazine-7-carboxylic acid 
• 1217299-46-1 5-benzoyl-3-methylpyrrolo[2,1-b]thiazole-7-carbonitrile 
• 1217299-47-2 methyl 5-benzoyl-3-methylpyrrolo[2,1-b]thiazole-7-carboxylate 
• 1310572-69-0 5-benzoyl-3-methylpyrrolo[2,1-b]thiazole-7-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and antiproliferative activity of multisubstituted N-fused heterocycles against the Hep-G2 cancer cell line

Pyrrolo[1,2-a]imidazole and pyrrolo[2,1-b]thiazole derivatives were synthesized in a one-pot procedure by [3 + 2] cycloaddition reactions of the corresponding imidazolium ylides and thiazolium ylides with an alkene followed by oxidative aromatization of t

Methods of Treating or Preventing Cardiac Disease Associated With a High Fat Diet

The present invention relates to a method of treating or preventing cardiac disorders, myocardial inflammation or myocardial oxidative stress associated with a high fat diet or in a patient subjected to a high fat diet using the thiazolium compounds and compositions of the invention. The present invention also relates to a method of ameliorating weight gain, myocardial AGE accumulation associated, mitochondrial superoxide production, RAGE expression or PPARα expression with a high fat diet or in a patient subjected to a high fat diet using the thiazolium compounds and compositions of the invention.

Method and composition for rejuvenating hair, nails, tissues, cells and organs by ex-vivo or immersive treatment

A method and composition for the treatment of hair, nail, ex-vivo organ, ex-vivo cell or ex-vivo tissue to improve the biomechanical and diffusional characteristics comprising an effective amount of a compound selected from the group consisting of compounds of the formula

Method for treating fibrotic diseases or other indications IC

Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I:

Preventing and reversing the formation of advanced glycosylation endproducts

The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

Preventing and reversing advanced glycosylation endproducts

The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a thiazolium compound capable of inhibiting, and to some extent reversing, the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

Reinvestigation of reactions of thiazolium and benzothiazolium N-phenacylides with electron-deficient acetylenes

Reactions of thiazolium and benzothiazolium N-phenacylides with dimethyl acetylenedicarboxylate (DMAD) have been reexamined. The thiazolium N-phenacylides 5, generated in situ from 4-methyl- or 5-phenyl-3-phenacylthiazolium bromides 13 with triethylamine,