6274-24-4

Usage

Uses

Used in Pharmaceutical Industry:
3-AMINO-PHENOXY-ACETIC ACID is used as a reactant or reagent for the preparation of pyrimidinylaminothiazoles. These compounds serve as dual-action hypoglycemic agents, activating both GK (glucokinase) and PPARγ (peroxisome proliferator-activated receptor gamma) enzymes. This dual activation mechanism holds promise for the potential treatment of diabetes, as it can help regulate blood sugar levels and improve insulin sensitivity in patients.

InChI:InChI=1/C8H9NO3/c9-6-2-1-3-7(4-6)12-5-8(10)11/h1-4H,5,9H2,(H,10,11)

Upstream product

• 1878-88-2 2-(3-nitrophenoxy)acetic acid 
• 621-42-1 meta-hydroxyacetanilide 
• 6339-04-4 2-(3-acetamidophenoxy)acetic acid 

Downstream Products

• 58559-52-7 3-aminophenoxyacetic acid ethyl ester 
• 1878-93-9 (3-iodophenoxy)acetic acid 
• 861343-18-2 [3-(2-chloro-acetylamino)-phenoxy]-acetic acid 
• 5544-78-5 (3-amino-phenoxy)-acetic acid ethyl ester; hydrochloride 
• 462067-31-8 3-tetrazol-1-ylphenoxyacetic acid 
• 847606-75-1 [3-(5-methyl-tetrazol-1-yl)-phenoxy]-acetic acid 
• 847606-68-2 (3-azidophenoxy)-acetic acid 
• 847606-79-5 (3-[1,2,4]-triazol-4-yl-phenoxy)-acetic acid 
• 820220-88-0 KNI-10087 
• 188751-53-3 2-(3-((tert-butoxycarbonyl)amino)phenoxy)acetic acid 
• 847606-67-1 N-[4-chloro-3-(trifluoromethyl)phenyl]-2-{[3-(1H-1,2,3-triazol-1-yl)phenyl]oxy}acetamide 

Relevant academic research and scientific papers

Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin

Plasmepsin (Plm) is a potential target for new antimalarial drugs, but most reported Plm inhibitors have relatively low antimalarial activities. We synthesized a series of dipeptide-type HIV protease inhibitors, which contain an allophenylnorstatine-dimethylthioproline scaffold to exhibit potent inhibitory activities against Plm II. Their activities against Plasmodium falciparum in the infected erythrocyte assay were largely different from those against the target enzyme. To improve the antimalarial activity of peptidomimetic Plm inhibitors, we attached substituents on a structure of the highly potent Plm inhibitor KNI-10006. Among the derivatives, we identified alkylamino compounds such as 44 (KNI-10283) and 47 (KNI-10538) with more than 15-fold enhanced antimalarial activity, to the sub-micromolar level, maintaining their potent Plm II inhibitory activity and low cytotoxicity. These results suggest that auxiliary substituents on a specific basic group contribute to deliver the inhibitors to the target Plm.

PYRROLE DERIVATIVES AS THERAPEUTIC COMPOUNDS

Novel pyrrole derivatives are disclosed as Aβ42-lowering agents for the treatment and prevention of neurodegenerative disorders characterized by the formation or accumulation of amyloid plaques comprising the Aβ42 peptide.

C-KIT MODULATORS AND METHODS OF USE

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Even more specifically, the invention

Gamma-Glutamyl-4-azoanilides

The present invention provides gamma-glutamyl-4-azoanilides, processes for their preparation and their use as substrates for gamma-glutamyl transferase determination, of the formula STR1 wherein X is alkyl, --(CH2)m --COOH or --O--(CH2)n --COOH wherein m is 0-4 and n is 1-4; R is optionally substituted p-nitrophenyl; an optionally substituted thiophene residue; an optionally substituted thiazole residue; an optionally substituted benzothiazole residue; an optionally substituted benzoisothiazole residue; an N-alkylthiazole residue; or an optionally substituted 1,3,5-thiodiazole residue; as well as the alkali metal, alkaline earth metal and ammonium salts thereof.