6274-24-4

Basic information

• Product Name: 3-AMINO-PHENOXY-ACETIC ACID
• Synonyms: 3-AMINO-PHENOXY-ACETIC ACID;(3-aminophenoxy)acetic acid(SALTDATA: FREE);2-(3-aMinophenoxy)acetic acid;Acetic acid,2-(3-aminophenoxy)-
• CAS NO: 6274-24-4
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• Mol File: 6274-24-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 373.7°C at 760 mmHg
• Flash Point: 179.8°C
• Appearance: /
• Density: 1.317g/cm³
• Vapor Pressure: 3.02E-06mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 3-AMINO-PHENOXY-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-PHENOXY-ACETIC ACID(6274-24-4)
• EPA Substance Registry System: 3-AMINO-PHENOXY-ACETIC ACID(6274-24-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 6274-24-4(Hazardous Substances Data)

Usage

Uses

(3-Aminophenoxy)acetic Acid is a reactant or reagent used in the preparation of pyrimidinylaminothiazoles as dual-action hypoglycemic agents that activate GK and PPARγ enzymes for potential treatment of diabetes.

InChI:InChI=1/C8H9NO3/c9-6-2-1-3-7(4-6)12-5-8(10)11/h1-4H,5,9H2,(H,10,11)

Upstream product

• 1878-88-2 2-(3-nitrophenoxy)acetic acid 
• 621-42-1 meta-hydroxyacetanilide 
• 6339-04-4 2-(3-acetamidophenoxy)acetic acid 

Downstream Products

• 58559-52-7 3-aminophenoxyacetic acid ethyl ester 
• 1878-93-9 (3-iodophenoxy)acetic acid 
• 861343-18-2 [3-(2-chloro-acetylamino)-phenoxy]-acetic acid 
• 5544-78-5 (3-amino-phenoxy)-acetic acid ethyl ester; hydrochloride 
• 847606-67-1 N-[4-chloro-3-(trifluoromethyl)phenyl]-2-{[3-(1H-1,2,3-triazol-1-yl)phenyl]oxy}acetamide 
• 188751-53-3 2-(3-((tert-butoxycarbonyl)amino)phenoxy)acetic acid 
• 847606-79-5 (3-[1,2,4]-triazol-4-yl-phenoxy)-acetic acid 
• 847606-68-2 (3-azidophenoxy)-acetic acid 
• 847606-75-1 [3-(5-methyl-tetrazol-1-yl)-phenoxy]-acetic acid 
• 462067-31-8 3-tetrazol-1-ylphenoxyacetic acid 
• 820220-88-0 KNI-10087 

Relevant articles and documents

Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin

Plasmepsin (Plm) is a potential target for new antimalarial drugs, but most reported Plm inhibitors have relatively low antimalarial activities. We synthesized a series of dipeptide-type HIV protease inhibitors, which contain an allophenylnorstatine-dimethylthioproline scaffold to exhibit potent inhibitory activities against Plm II. Their activities against Plasmodium falciparum in the infected erythrocyte assay were largely different from those against the target enzyme. To improve the antimalarial activity of peptidomimetic Plm inhibitors, we attached substituents on a structure of the highly potent Plm inhibitor KNI-10006. Among the derivatives, we identified alkylamino compounds such as 44 (KNI-10283) and 47 (KNI-10538) with more than 15-fold enhanced antimalarial activity, to the sub-micromolar level, maintaining their potent Plm II inhibitory activity and low cytotoxicity. These results suggest that auxiliary substituents on a specific basic group contribute to deliver the inhibitors to the target Plm.

C-KIT MODULATORS AND METHODS OF USE

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Even more specifically, the invention

Potential anticancer agents--L. Non-classical antimetabolites. II. Some factors in the design of exoalkylating enzyme inhibitors, particulary of lactic dehydrogenase.

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