Cas 627461-80-7,[4-Amino-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl]-(3-fluoro-phenyl)-methanone

627461-80-7

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Basic information

Product Name: [4-Amino-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl]-(3-fluoro-phenyl)-methanone
Synonyms: [4-Amino-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl]-(3-fluoro-phenyl)-methanone
CAS NO:627461-80-7
Molecular Formula:
Molecular Weight: 426.515
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: [4-Amino-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl]-(3-fluoro-phenyl)-methanone(CAS DataBase Reference)
NIST Chemistry Reference: [4-Amino-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl]-(3-fluoro-phenyl)-methanone(627461-80-7)
EPA Substance Registry System: [4-Amino-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl]-(3-fluoro-phenyl)-methanone(627461-80-7)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
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Hazardous Substances Data: 627461-80-7(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 627461-80-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,7,4,6 and 1 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 627461-80:
(8*6)+(7*2)+(6*7)+(5*4)+(4*6)+(3*1)+(2*8)+(1*0)=167
167 % 10 = 7
So 627461-80-7 is a valid CAS Registry Number.

627461-80-7Upstream product

53631-18-8 2-bromo-1-(3-fluorophenyl)ethanone

627461-80-7Downstream Products

627461-80-7Relevant academic research and scientific papers

DIAMINOTHIAZOLES

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Page/Page column 36, (2010/02/05)

The present invention is directed to novel diaminothiazoles of formula These compounds inhibit cyclin-dependent kinase 4 (Cdk4) and are selective against Cdk2 and Cdk1. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment 6r control of breast, lung and colon and prostate tumors.

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