6275-99-6

Basic information

• Product Name: N-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoroacetamide
• Synonyms: N-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoroacetamide
• CAS NO: 6275-99-6
• Molecular Formula: C8H7F3N2O3S
• Molecular Weight: 268.2129896
• Mol File: 6275-99-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.597g/cm³
• Refractive Index: 1.538
• CAS DataBase Reference: N-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoroacetamide(6275-99-6)
• EPA Substance Registry System: N-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoroacetamide(6275-99-6)

Safety Data

• Hazardous Substances Data: 6275-99-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H7F3N2O3S/c9-8(10,11)7(14)13-5-1-3-6(4-2-5)17(12,15)16/h1-4H,(H,13,14)(H2,12,15,16)

Upstream product

• 354-32-5 trifluoracetyl chloride 
• 63-74-1 sulfanilamide 
• 407-25-0 trifluoroacetic anhydride 

Relevant articles and documents

COMPOSITIONS AND METHODS FOR THE TREATMENT OF PLATINUM-DRUG RESISTANT CANCER

VAR2CSA-drug conjugates for targeting and inhibiting the growth of cancer cells that have developed resistance to a platinum drug and the use of the conjugates in the treatment of platinum drug-resistant cancers. VAR2CSA-drug conjugates (VDCs) comprise a

SULFONAMIDE-CONTAINING LINKAGE SYSTEMS FOR DRUG CONJUGATES

Sulfonamide-containing linkage systems for release of payload compounds from an attached targeting moiety in drug conjugates. The conjugates have the formula of [(P)-(L)]m-(T), wherein (P) is a payload compound, (L) is a linker, (T) is a targeting moiety and m is an integer from 1- to 10. Also provided are pharmaceutical compositions comprising such conjugates and there use in treating cancer.

Condensation reactions of trifluoronitrosomethane CF3NO with sulfanilamide H2NC6H4SO2NH2 - Preparation of CF3NNC6H4SO2NH2, CF3NNC6H4SO2NNCF3, CH3C(O)N(H)C6H4SO2NNCF3

We report the condensations of trifluoronitrosomethane with sulfanilamide. The new compounds p-trifluoromethylazophenylsulfonamide CF3NNC6H4SO2NH2, p-trifluoromethylazosulfonyltrifluoromethylazobenzole CF3NNC6H4SO2NNCF3 and p-trifluoromethylazosulfonyl-acetanilide CH3C(O)N(H)C6H4SO2NNCF3 were characterized by elemental analysis, IR, Raman, mass, 1H, 19F and 13C NMR spectroscopy. In addition we present our approach to the preparation of p-trifluoromethylazosulfonylaniline H2NC6H4SO2NNCF3 by using protecting groups for the amino group.