627531-51-5

Basic information

• Product Name: 2-Quinolinecarbonitrile,6-amino-(9CI)
• Synonyms: 2-Quinolinecarbonitrile,6-amino-(9CI);6-amino-2-Quinolinecarbonitrile
• CAS NO: 627531-51-5
• Molecular Formula: C₁₀H₇N₃
• Molecular Weight: 169.186
• Product Categories: ISOQUINOLINE
• Mol File: 627531-51-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Quinolinecarbonitrile,6-amino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Quinolinecarbonitrile,6-amino-(9CI)(627531-51-5)
• EPA Substance Registry System: 2-Quinolinecarbonitrile,6-amino-(9CI)(627531-51-5)

Safety Data

• Hazardous Substances Data: 627531-51-5(Hazardous Substances Data)

Upstream product

• 580-15-4 6-aminoquinoline 
• 1374108-77-6 6-((tert-butoxycarbonyl)amino)quinoline-N-oxide 
• 13675-93-9 2-cyano-6-nitroquinoline 
• 13675-92-8 6-nitroquinoline-N-oxide 
• 613-50-3 6-nitroquinoline 

Relevant articles and documents

ANDROGEN RECEPTOR LIGANDS

Described are compounds that inhibit androgen receptor action, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.

Development of luciferin analogues bearing an amino group and their application as BRET donors

We systematically synthesized bioluminogenic substrates bearing an amino group on benzothiazole, quinoline, naphthalene, and coumarin scaffolds. They emit bioluminescence in various colors: red, orange, yellow, and green. An amino-substituted cou-marylluciferin derivative, coumarylami-noluciferin (CAL), showed the shortest bioluminescence wavelength among substrates reported so far. Further, the fluorescence of CAL did not exhibit solvatochromism, which suggests that its bioluminescence is not susceptible to environmental factors. We applied CAL as an energy-donor substrate for a bioluminescence resonance energy transfer (BRET) system with click beetle red luciferase (CBRluc), a mutant of firefly luciferase, as the energy-donor enzyme and yellow fluorescent protein (YFP) as the energy-acceptor fluorophore, and obtained a clearly bimodal bioluminescence spectrum. Stable bioluminescence that is not influenced by environmental factors is highly desirable for reliable measurements in biological assays.

Bicyclic modulators of androgen receptor function

The invention provides for a pharmaceutical composition capable of modulating the androgen receptor comprising a compound of formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.

BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION

The invention provides compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.