627535-87-9

Basic information

• Product Name: 3-(4-fluoro-3-nitro-phenyl)-2-(2-{[3-(3-hydroxy-phenyl)-propionyl]-isopropyl-amino}-4-phenyl-butyrylamino)-propionic acid methyl ester
• Synonyms: 3-(4-fluoro-3-nitro-phenyl)-2-(2-{[3-(3-hydroxy-phenyl)-propionyl]-isopropyl-amino}-4-phenyl-butyrylamino)-propionic acid methyl ester
• CAS NO: 627535-87-9
• Molecular Weight: 593.652
• Mol File: 627535-87-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(4-fluoro-3-nitro-phenyl)-2-(2-{[3-(3-hydroxy-phenyl)-propionyl]-isopropyl-amino}-4-phenyl-butyrylamino)-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-fluoro-3-nitro-phenyl)-2-(2-{[3-(3-hydroxy-phenyl)-propionyl]-isopropyl-amino}-4-phenyl-butyrylamino)-propionic acid methyl ester(627535-87-9)
• EPA Substance Registry System: 3-(4-fluoro-3-nitro-phenyl)-2-(2-{[3-(3-hydroxy-phenyl)-propionyl]-isopropyl-amino}-4-phenyl-butyrylamino)-propionic acid methyl ester(627535-87-9)

Safety Data

• Hazardous Substances Data: 627535-87-9(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 621-54-5 3-(3-hydroxyphenyl)-propanoic acid 
• 75-31-0 isopropylamine 
• 389635-00-1 3-(4-fluoro-3-nitrophenyl)-2-isocyanopropionic acid methyl ester 
• 26029-57-2 N-(3-Phenyl-propyliden)-isopropylamin 

Relevant articles and documents

Rapid and diverse route to natural product-like biaryl ether containing macrocycles

A two-step sequence involving an Ugi four-component reaction and an intramolecular nucleophilic aromatic substitution (SNAr) has been developed for the rapid access to biaryl-ether containing macrocycles. In the course of this study, we documented that ammonium chloride can promote the Ugi-4CR in non-polar aprotic solvent (toluene) without the interference of an alternative Passerini reaction. Solid phase synthesis of macrocycles by this two-step sequence was also developed using polymer (Wang resin) supported α-(4′-fluoro-3′-nitro)phenethyl isocyanoacetate as one of the inputs.