627541-35-9Relevant articles and documents
Microwave-Assisted [3 + 2] Cycloadditions of Azomethine Ylides
Bashiardes, George,Safir, Imad,Mohamed, Achmet Said,Barbot, Francis,Laduranty, Joelle
, p. 4915 - 4918 (2007/10/03)
(Equation Presented) The microwave-assisted intramolecular [3 + 2] cycloaddition reaction of azomethine ylides to activated and nonactivated alkenes and alkynes is described. The procedure allows the synthesis of pyrrolidines and pyrrole products in good to excellent overall yields in short reaction times. It appears from parallel comparative studies that the microwave procedure favors the reaction times and overall purity of the crude reaction mixture. The reactions can also be performed in the absence of solvent.
A new method for the synthesis of plurisubstituted pyrroles
Bashiardes, George,Safir, Imad,Barbot, Francis,Laduranty, Joelle
, p. 8417 - 8420 (2007/10/03)
A versatile method for the synthesis of pyrroles is described using an intramolecular [3+2] cycloaddition reaction. This method allows the expedient preparation of 'plurisubstituted' compounds in which functionality is incorporated by choice, using appropriate readily available starting materials. Polycyclic pyrrole derivatives as well as 2-aryl monocyclic analogues are described. Several families of compounds are synthesized by sequential transformations. The method is designed to allow the creation of libraries with increased diversity of functionality by combinatorial or parallel synthesis.