62777-90-6

Basic information

• Product Name: 5,6ALPHA-DIHYDRO PGI2
• Synonyms: 5,6ALPHA-DIHYDRO PGI2;6R,9ALPHA-EPOXY-11ALPHA,15S-DIHYDROXY-PROST-13E-EN-1-OIC ACID;6ALPHA-PROSTAGLANDIN I1;(6R,13E,15S)-6,9α-Epoxy-11α,15-dihydroxyprost-13-en-1-oic acid;6α-Prostaglandin I1;RJADQDXZYFCVHV-WDONHGPHSA-N
• CAS NO: 62777-90-6
• Molecular Formula: C20H34O5
• Molecular Weight: 354.48
• Mol File: 62777-90-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5,6ALPHA-DIHYDRO PGI2(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6ALPHA-DIHYDRO PGI2(62777-90-6)
• EPA Substance Registry System: 5,6ALPHA-DIHYDRO PGI2(62777-90-6)

Safety Data

• Hazardous Substances Data: 62777-90-6(Hazardous Substances Data)

Upstream product

• 77973-09-2 5-{(2S,3aR,4R,5S,6S,6aR)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-6-iodo-hexahydro-cyclopenta[b]furan-2-yl}-pentan-1-ol 
• 75683-21-5 5-{(2R,3aS,4S,5R,6R,6aS)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-6-iodo-hexahydro-cyclopenta[b]furan-2-yl}-pentanoic acid 
• 77973-06-9 (2R,3aS,4S,5S,6aR)-4-((E)-3-Hydroxy-oct-1-enyl)-2-(5-hydroxy-pentyl)-hexahydro-cyclopenta[b]furan-5-ol 
• 78478-37-2 methyl (6R,9α,11α,13E,15S)-6,9-epoxy-11,15-dihydroxy-5-(phenylseleno)-prosta-13-en-1-oate 
• 33854-16-9 (+)-prostaglandin F_2α 
• 65866-08-2 methyl (6R,9α,11α,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-13-en-1-oate 

Relevant articles and documents

Synthesis of (+/-)-6β-Prostaglandin I1 and (+/-)-6β-Decarboxyprostaglandin I1

The known hydroxy-aldehyde (5) has been converted into 6β-decarboxyprostaglandin I1 (19) and 6β-prostaglandin I1 (3) by (i) reaction with an appropriate organometallic reagent, (ii) cyclisation via the intermediate formation of an iodonium ion, and (iii) hydrodeiodination and desilylation.

Total Synthesis of (+/-)-6β-Prostaglandin I1

(+/-)-6β-Prostaglandin I1 (3) has been prepared from the readily available unsaturated aldehyde (6) in four steps.