62786-72-5Relevant academic research and scientific papers
A convenient preparation of benzyl 4-(R1)-3-(R2)pyrrole-2-carboxylates
Burns,Jabara,Burden
, p. 379 - 387 (2007/10/02)
The class of title pyrroles, important intermediates in porphyrin synthesis, have been prepared via the Barton and Zard method. The benzyl isocyanoacetate used in the synthesis was in turn prepared in an efficient and inexpensive 3-step procedure from glycine.
Regioselective synthesis of 5-unsubstituted benzyl pyrrole-2-carboxylates from benzyl isocyanoacetate
Ono,Katayama,Nisyiyama,Ogawa
, p. 707 - 710 (2007/10/02)
A general synthesis of 5-unsubstituted benzyl pyrrole-2-carboxylates was developed based on the reaction of β-nitroacetates with benzyl isocyanoacetate. The advantage of this route over other pyrrole syntheses was the regiochemical control of the substitution pattern on the pyrrole ring.
An Improved Synthesis of Pyrroles from N-p-Toluenesulfonylglycine Esters and α,β-Unsaturated Aldehydes and Ketones
Lash, Timothy D.,Hoehner, Michael C.
, p. 1671 - 1676 (2007/10/02)
N-p-Toluenesulfonylglycine esters 2 condensed with α,β-unsaturated carbonyl compounds 1 in the presence of the non-nucleophilic base DBU to give hydroxypyrrolidines 3.Dehydration with phosphorous oxychloride-pyridine, followed by DBU mediated elimination
