6279-34-1

Basic information

• Product Name: 1-bromo-2-[(4-methylphenoxy)methyl]benzene
• CAS NO: 6279-34-1
• Molecular Formula: C₁₄H₁₃BrO
• Molecular Weight: 277.1564
• Mol File: 6279-34-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 358.3°C at 760 mmHg
• Flash Point: 145.8°C
• Density: 1.341g/cm³
• Vapor Pressure: 5.29E-05mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 1-bromo-2-[(4-methylphenoxy)methyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-[(4-methylphenoxy)methyl]benzene(6279-34-1)
• EPA Substance Registry System: 1-bromo-2-[(4-methylphenoxy)methyl]benzene(6279-34-1)

Safety Data

• Hazardous Substances Data: 6279-34-1(Hazardous Substances Data)

Usage

Benzene derivative

The compound is derived from benzene, which means it is a chemical structure that has a benzene ring as its base or core.

Bromine atom at position 1

The compound has a bromine atom attached to the first carbon atom of the benzene ring, which can influence its reactivity and properties.

2-[(4-methylphenoxy)methyl] group at position 2

A substituent group consisting of a 4-methylphenoxy attached to a methyl group is attached to the second carbon atom of the benzene ring, further affecting the compound's properties and reactivity.

Commonly used in organic synthesis

The compound is frequently employed as a building block or intermediate in the synthesis of more complex organic molecules.

Utilized as a reagent

1-bromo-2-[(4-methylphenoxy)methyl]benzene can participate in various chemical reactions, making it a valuable tool in the field of chemistry.

Potential applications in pharmaceutical and agrochemical industries

The compound may have uses in the development of new drugs or agrochemicals due to its unique structure and reactivity.

Specific properties and uses vary

The exact properties and applications of 1-bromo-2-[(4-methylphenoxy)methyl]benzene depend on the specific requirements and goals of the synthesis or process in which it is used.

Upstream product

• 106-44-5 p-cresol 
• 578-51-8 2-bromobenzylchloride 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 95-46-5 2-methylphenyl bromide 

Downstream Products

• 850355-33-8 2-(2-benzyloxy-5-methyl-benzyl)-benzonitrile 
• 850355-22-5 1-Benzyloxy-2-(2-bromo-benzyl)-4-methyl-benzene 
• 791821-94-8 4-methyl-2-[(2-cyanophenyl)methyl]phenol 
• 791821-95-9 4-methyl-2-[(2-formylphenyl)methyl]phenol 
• 5468-74-6 2-(2-bromo-benzyl)-4-methyl-phenol 

Relevant articles and documents

Impregnated palladium on magnetite as catalyst for direct arylation of heterocycles

Palladium impregnated on magnetite is an efficient, cheap and easy to prepare catalyst for the direct arylation of heterocycles. Good yields are afforded under relatively mild conditions and a broad substrate scope is evident. The catalyst is regioselective in many cases, affording arylated products, at the C2- or C3-position (depending of the heterocycle used). The methodology can be extended to prepare chromenes through an intramolecular direct arylation reaction. Some evidence is provided for two catalyst deactivation pathways, which prevents efficient recycling.

Intramolecular 9-membered hydrogen bonding of 2-arylmethylphenols having carbonyl groups at 2′-position

Thermodynamic parameters of nine-membered intramolecular hydrogen bonding between carbonyl groups and phenolic hydroxyl groups of 2-arylmethylphenols having methoxycarbonyl, dimethylcarbamoyl, and formyl groups were determined by variable temperature 1H NMR studies and van't Hoff analysis. The enthalpy of the hydrogen bonding was related to the electron-withdrawing ability of the substituents on the phenol and the basicity of the carbonyl group. The entropy loss of the hydrogen bonding was dependent on the rotation freedom of the phenol group. The enthalpy of nine-membered intramolecular hydrogen bonding between carbonyl groups and phenolic hydroxyl groups of 2-arylmethylphenols was related to the electron-withdrawing ability of the substituents on the phenol and the basicity of the carbonyl group. The entropy loss was dependent on the rotation freedom of the phenol group.