627902-05-0

Basic information

• Product Name: Ethanol, 2-[4-(trifluoroMethoxy)phenoxy]-
• Synonyms: Ethanol, 2-[4-(trifluoroMethoxy)phenoxy]-;2-(4-(trifluoromethoxy)phenoxy)ethanol
• CAS NO: 627902-05-0
• Molecular Formula: C₉H₉F₃O₃
• Molecular Weight: 222.1611696
• Mol File: 627902-05-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanol, 2-[4-(trifluoroMethoxy)phenoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-[4-(trifluoroMethoxy)phenoxy]-(627902-05-0)
• EPA Substance Registry System: Ethanol, 2-[4-(trifluoroMethoxy)phenoxy]-(627902-05-0)

Safety Data

• Hazardous Substances Data: 627902-05-0(Hazardous Substances Data)

Upstream product

• 828-27-3 4-Trifluoromethoxyphenol 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 1418287-64-5 ethyl 5-cyano-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylate 
• 1418287-67-8 ethyl 5-bromo-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylate 
• 1418287-14-5 5-cyano-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylic acid 
• 1418287-68-9 ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2-[4-(trifluoromethoxy)phenoxy]ethyl)-1H-indole-2-carboxylate 
• 1418287-16-7 5-(pyrazin-2-yl)-1-(2-[4-(trifluoromethoxy)phenoxy]ethyl)-1H-indole-2-carboxylic acid 
• 1418287-18-9 5-(1H-pyrazol-3-yl)-1-{2-[4-(trifluoromethoxy)phenoxy]ethyl}-1H-indole-2-carboxylic acid 
• 1614229-16-1 ethyl 5-(1-(phenylsulfonyl)-1H-pyrazol-3-yl)-1-(2-(4-(trifluoromethoxy)phenoxy)ethyl)-1H-indole-2-carboxylate 
• 1611492-77-3 C₁₂H₁₃F₃O₄ 
• 1579960-94-3 1-(4-(2-(tert-butyl)phenyl)piperazin-1-yl)-3-(2-(4-(trifluoromethoxy)phenoxy)ethoxy)propan-2-ol 
• 1333170-23-2 (6S)-2-nitro-6-{2-[4-trifluoromethoxyphenoxy]ethoxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine 
• 1333171-24-6 1-(2-iodoethoxy)-4-trifluoromethoxybenzene 

Relevant articles and documents

SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF

Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold

Previously, we identified 1-(2-(4-bromophenoxy)ethoxy)-3-(4-(2- methoxyphenyl)piperazin-1-yl)propan-2-ol (1) as a novel Hsp90 inhibitor with moderate activity through virtual screening. In this study, we report the optimization process of 1. A series of analogues containing the 1-phenylpiperazine core scaffold were synthesized and evaluated. The structure-activity relationships (SAR) for these compounds was also discussed for further molecular design. This effort afforded the most active inhibitor 13f with improved activity in not only target-based level, but also cell-based level compared with the original hit 1.

TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF

The present invention is directed to compounds of formula I and la: which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, t