6280-32-6

Usage

Chemical Structure

1-(2H-1,2,3,4-TETRAAZOL-5-YL)PIPERIDINE is a heterocyclic compound with a piperidine ring attached to a tetraazolyl ring.

Composition

The compound contains both nitrogen and carbon atoms in its structure.

Tetraazolyl Ring

A five-membered ring with four nitrogen atoms and one carbon atom.

Piperidine Ring

A six-membered ring with one nitrogen atom.

Potential Applications

It has potential applications in the pharmaceutical industry, particularly in the development of new drugs and medications.

Handling and Safety

It is important to handle and use this chemical with care, as it may have reactivity and toxicity hazards.

Heterocyclic Compound

It is a type of compound that contains atoms of different elements in its ring structure.

Nitrogen Content

The compound has a high nitrogen content due to the presence of multiple nitrogen atoms in both the tetraazolyl and piperidine rings.

InChI:InChI=1/C6H11N5/c1-2-4-11(5-3-1)6-7-9-10-8-6/h1-5H2,(H,7,8,9,10)

Upstream product

• 1530-87-6 1-piperidinylcarbonnitrile 
• 656835-57-3 C-benzotriazol-1-yl-C-piperidin-1-yl-methyleneamine 
• 110-89-4 piperidine 
• 764-05-6 cyanogen azide 

Relevant academic research and scientific papers

Synthesis of 5-Substituted 1 H-Tetrazoles from Nitriles by Continuous Flow: Application to the Synthesis of Valsartan

An efficient continuous flow process for the synthesis of 5-substituted 1H-tetrazoles is described. The process involves the reaction between a polymer-supported triorganotin azide and organic nitriles. The polymer-supported organotin azide, which is in situ generated with a polystyrene-supported triorganotin alkoxide and trimethylsilylazide, is immobilized in a packed bed reactor. This approach is simple, fast (it takes from 7.5 to 15 min), and guarantees a low concentration of tin residues in the products (5 ppm). The process was developed to aryl-, heteroaryl-, and also alkylnitriles and was applied for the synthesis of valsartan, an angiotensin II receptor antagonist.

Fimctlonalized tetrazoles from cyanogen azide with secondary amines

Secondary amines react with cyanogen azide at ambient temperature in water/acetonitrile to provide tetrazole derivatives directly. The scope and limitations with regard to steric hindrance of the amine are discussed. Although reaction yields are moderate, 29-81%, the cyanogen azide reactions provide a direct and versatile route to functionalized tetrazoles that: may be especially useful considering the diversity of amines suitable for this transformation.

A general route to 5-aminotetrazoles

Various di- and trisubstituted (benzotriazolyl)- carboximidamides were used for the preparation of N,N-di-and 1,N,N-trisubstituted 5-aminotetrazoles 3a-e and 6a-d under mild conditions in good to excellent yields.